SIMONI, Daniele
 Distribuzione geografica
Continente #
NA - Nord America 13.567
AS - Asia 5.549
EU - Europa 3.528
SA - Sud America 861
AF - Africa 80
Continente sconosciuto - Info sul continente non disponibili 11
OC - Oceania 9
Totale 23.605
Nazione #
US - Stati Uniti d'America 13.368
SG - Singapore 2.100
CN - Cina 1.753
DE - Germania 793
BR - Brasile 719
UA - Ucraina 707
TR - Turchia 589
HK - Hong Kong 474
IT - Italia 463
GB - Regno Unito 437
VN - Vietnam 311
SE - Svezia 305
FI - Finlandia 215
RU - Federazione Russa 183
FR - Francia 107
CA - Canada 101
PL - Polonia 94
MX - Messico 85
IN - India 72
NL - Olanda 56
AR - Argentina 53
JP - Giappone 40
ZA - Sudafrica 40
BE - Belgio 39
BD - Bangladesh 33
ES - Italia 33
ID - Indonesia 31
IQ - Iraq 22
EC - Ecuador 20
CL - Cile 19
CZ - Repubblica Ceca 19
LT - Lituania 17
PK - Pakistan 16
PY - Paraguay 16
KR - Corea 15
MA - Marocco 15
AE - Emirati Arabi Uniti 12
IR - Iran 11
AT - Austria 10
CO - Colombia 10
IE - Irlanda 10
SA - Arabia Saudita 10
EU - Europa 9
JO - Giordania 9
VE - Venezuela 9
AU - Australia 8
RO - Romania 7
TW - Taiwan 7
CH - Svizzera 6
UY - Uruguay 6
EG - Egitto 5
IL - Israele 5
NO - Norvegia 5
PE - Perù 5
DZ - Algeria 4
HU - Ungheria 4
MY - Malesia 4
PH - Filippine 4
AL - Albania 3
BG - Bulgaria 3
BO - Bolivia 3
GA - Gabon 3
KE - Kenya 3
KG - Kirghizistan 3
KH - Cambogia 3
LB - Libano 3
TT - Trinidad e Tobago 3
UZ - Uzbekistan 3
A2 - ???statistics.table.value.countryCode.A2??? 2
AO - Angola 2
AZ - Azerbaigian 2
BH - Bahrain 2
BN - Brunei Darussalam 2
DM - Dominica 2
GE - Georgia 2
GR - Grecia 2
MN - Mongolia 2
MT - Malta 2
NI - Nicaragua 2
NP - Nepal 2
OM - Oman 2
PA - Panama 2
PT - Portogallo 2
RS - Serbia 2
TN - Tunisia 2
AF - Afghanistan, Repubblica islamica di 1
BA - Bosnia-Erzegovina 1
BB - Barbados 1
BW - Botswana 1
BY - Bielorussia 1
CD - Congo 1
CI - Costa d'Avorio 1
DK - Danimarca 1
EE - Estonia 1
ET - Etiopia 1
GT - Guatemala 1
GY - Guiana 1
JM - Giamaica 1
KW - Kuwait 1
NG - Nigeria 1
Totale 23.599
Città #
Fairfield 1.464
Woodbridge 1.295
Ashburn 1.236
Singapore 1.233
Houston 896
Dallas 871
Jacksonville 774
Chandler 706
Seattle 655
Ann Arbor 631
Beijing 524
Wilmington 521
Santa Clara 516
Hong Kong 470
Cambridge 464
Izmir 248
Nanjing 242
New York 216
Los Angeles 162
Princeton 157
Boardman 146
Munich 137
San Diego 137
Addison 102
Ho Chi Minh City 87
Shanghai 81
Shenyang 76
São Paulo 75
Warsaw 74
Nanchang 71
Milan 64
Hefei 63
The Dalles 63
London 61
Mexico City 61
Chicago 60
Tianjin 60
Ferrara 58
Hebei 57
Changsha 56
Hanoi 55
Dong Ket 54
San Mateo 54
Jinan 42
Bremen 41
Turku 40
Brussels 39
Frankfurt am Main 36
Falkenstein 35
Brooklyn 33
Jiaxing 33
Falls Church 32
San Francisco 32
Tokyo 32
Helsinki 31
Montreal 31
Moscow 31
Amsterdam 30
Chennai 29
Buffalo 28
Philadelphia 27
Verona 24
Rio de Janeiro 23
Atlanta 22
Boston 22
Guangzhou 22
Auburn Hills 21
Denver 21
Norwalk 21
Bologna 20
Toronto 20
Mountain View 19
Phoenix 19
Poplar 18
Belo Horizonte 17
Brasília 17
Jakarta 17
Kunming 17
Orem 17
Washington 17
Zhengzhou 17
Dearborn 16
Redwood City 16
Hangzhou 15
Mcallen 15
Salt Lake City 15
Stockholm 15
Taizhou 15
Johannesburg 14
Rome 14
Des Moines 13
Haiphong 12
Montréal 12
Ankara 11
Augusta 11
Charlotte 11
Da Nang 11
Goiânia 11
Indiana 11
Manchester 11
Totale 16.275
Nome #
1,2,4-triazoles. Improved synthesis of 5-substituited 4-amino-3mercato-(4H)-1,2,4 triazoles and a facile route to 3,6-disubstituited 1,24-triazolo[3,4b][1,3,4]thiadiazoles 1.093
1,5,7-Triazabicyclo[4.4.0]dec-1-ene (TBD), 7-methyl-TBD (MTBD) and the polymer-supported TBD (P-TBD): Three efficient catalysts for the nitroaldol (Henry) reaction and for the addition of dialkyl phosphites to unsaturated systems 288
A facile, efficient synthesis of 2-substituted-4-hydroxy-2-cyclopenten-1-ones 245
4,5,6,7-Tetrahydro-isoxazolo-[4,5-c]-pyridines as a new class of cytotoxic Hsp90 inhibitors 241
3,5-Disubstituted isoxazoles as a latent aldol moiety: Application to the synthesis of (±)-[6]-gingerol 234
A [3+2] nitrile oxide intermolecular cycloaddition approach to 4,5-dihydro-3(2H)-furanone and 3(2H)-furanone ring systems: application to the formal synthesis of (±)-ascofuranone and geiparvarin. 232
Inhibition of activated STAT5 in Bcr/Abl expressing leukemia cells with new pimozide derivatives. 229
Development of hemiasterlin derivatives as potential anticancer agents that inhibit tubulin polymerization and synergize with a stilbene tubulin inhibitor 225
Retinoic acid conjugates as potential antitumor agents: Synthesis and biological activity of conjugates with Ara-A, Ara-C, 3(2H)-furanone, and aniline mustard moieties 225
A convenient synthesis of unsymmetrically substituted terphenyls of biologically active stilbenes via a double Suzuki cross-coupling protocol 224
Effects of Pimozide Derivatives on pSTAT5 in K562 Cells 221
A [3 + 2] nitrile oxide cycloaddition approach to retinoids 216
Hydropathic analysis and biological evaluation of stilbene derivatives as colchicine site microtubule inhibitors with anti-leukemic activity 216
New TRAP1 and Hsp90 chaperone inhibitors with cationic components: Preliminary studies on mitochondrial targeting 216
Arylamidonaphtalene sulfonate compounds as a novel class of heparanase inhibitors 213
A novel hybrid drug between two potent anti-tubulin agents as a potential prolonged anticancer approach 212
A new nitrile oxide based synthesis of the antitumor agent geiparvarin 205
3,5-Disubstituted Isoxazoles as Synthons for (±)-Pyrenophorin and (±)-Vermiculine Synthesis 203
Novel terphenyls and 3,5-diaryl isoxazole derivatives endowed with growth supporting and antiapoptotic properties 201
Effects of two-carbon bridge region methoxylation of benztropine: discovery of novel chiral ligands for the dopamine transporter 200
Design, synthesis and biological evaluation of novel stilbene-based antitumor agents 199
Heterocyclic and phenyl double-bond-locked combretastatin analogues possessing potent apoptosis-inducing activity in HL60 and in MDR cell lines 195
Development of water soluble derivatives of cis-3, 4', 5-trimethoxy-3'- aminostilbene for optimization and use in cancer therapy 194
Curcumin as a possible lead compound against hormone-independent, multidrug-resistant breast cancer 194
Novel iodoacetamido benzoheterocyclic derivatives with potent antileukemic activity are inhibitors of STAT5 phosphorylation 193
Novel A-ring and B-ring modified combretastatin A-4 (CA-4) analogues endowed with interesting cytotoxic activity 193
A new direct glycosylation of pyrimidine, pyrazole, imidazole and purine heterocycles via their N-tetrahydropyranyl (THP) derivatives 193
Ethyl 2,4-dioxoalkanoates as starting materials for a convenient route to 3(2H)-furanones and 3(2H)-furanimines 190
Hemiasterlin derivative (R)(S)(S)-BF65 and Akt inhibitor MK-2206 synergistically inhibit SKOV3 ovarian cancer cell growth 190
Geiparvarin analogs. 2. Synthesis and cytostatic activity of 5-(4-arylbutadienyl)-3(2H)-furanones and of N-substituted 3-(4-oxo-2-furanyl)-2-buten-2-yl carbamates. 188
Stilbene 5c, a microtubule poison with vascular disrupting properties that induces multiple modes of growth arrest and cell death 187
A one-pot glycosylation of tetrahydropyranyl (THP) ether intermediates 186
Methyl 4-oxothiolane-3-carboxylate and methyl 2-methyl-4-oxothiolane-3- carboxylate anions as synthetic equivalents of α-acrylate and α-crotonate anions. Formal synthesis of integerrinecic acid 181
Geiparvarin Analogs. 4.1. Synthesis and Cytostatic Activity of Geiparvarin Analogs Bearing a Carbamate Moiety or a Furocoumarin Fragment on the Alkenyl Side Chain 180
Cyclic guanidines: Synthesis of 4,6,7,8‐tetrahydro‐1H‐imidazo[1,2‐a]pyrazolo[3,4‐d]pyrimidin‐7‐ones and 1,4,6,7,8,9‐hexahydropyrazolo[3′,4′:4,5]pyrimido[2,1‐c] [1,2,4]triazin‐7‐ones 179
Synthesis of 8-oxa analogues of norcocaine endowed with interesting cocaine-like activity 179
Lack of nucleophilic addition in the isoxazole and pyrazole diketone modified analogs of curcumin; implications for their antitumor and chemosensitizing activities 179
Synthesis and biological evaluation of resveratrol and analogues as apoptosis-inducing agents 177
Preparation of 3,4-dihydroxy-1-benzeneethanol: a reinvestigation 176
Geiparvarin Analogs. 3. Synthesis and cytostatic activity of 3(2H)-furanone and 4,5-dihydro-3(2H)-furanone congeners of geiparvarin, containing a geraniol-like fragment in the side chain 175
Synthesis and pharmacology of 6-substituted benztropines: Discovery of novel dopamine uptake inhibitors possessing low binding affinity to the dopamine transporter 175
Studies on the apoptotic activity of natural and synthetic retinoids: Discovery of a new class of synthetic terphenyls that potently support cell growth and inhibit apoptosis in neuronal and HL-60 cells 174
Antitumor effects of curcumin and structurally β-diketone modified analogs on multidrug resistant cancer cells 171
The antitumor activities of curcumin and of its isoxazole analogue are not affected by multiple gene expression changes in an MDR model of the MCF-7 breast cancer cell line: Analysis of the possible molecular basis 170
Novel combretastatin analogues endowed with antitumor activity 169
Synthesis and cytotoxic activity of 6-vinyl- and 6-ethynyluridine and 8-vinyl- and 8-ethynyladenosine 167
Synthesis of syn- and anti-tricyclo [4.1.0.02,4] heptan-5-ones and related compounds 166
Synthesis of 2-(5-substituted isoxazol-3-yl)-4-oxo-3-thiazolidinyl alkanoic acids 164
Total Synthesis of (±) isoclovene 163
Heterocycle-containing retinoids. Discovery of a novel isoxazole arotinoid possessing potent apoptotic activity in multidrug and drug-induced apoptosis-resistant cells. 162
Sintesi di derivati pirazolici e pirazolo[4,3-d]pirimidonici. Nota II 160
Synthesis of 6‐substituted‐4,5‐dihydro‐3(2H)‐pyridazinones 158
Derivati isossazolici come induttori di emoglobina fetale in precursori eritroidi derivati da pazienti beta-talassemici 158
Concise enantioselective synthesis and attribution of the absolute configuration of two-carbon bridge methoxylated cocaines and pseudococaines 156
Synthesis of new pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine and 1,2,3-triazolo[4,5-e]1,2,4-triazolo[1,5-c]pyrimidine displaying potent and selective activity as A2a adenosine receptor antagonists 155
Enantioselective deprotonation of the 8-oxabicyclo[3.2.1]octan-3-one: Synthesis of 8-oxa-norcocaines and 8-oxa-pseudonorcocaines 154
Antitumor effects of new synthetic isoxazole derivatives 154
Design, synthesis, and biological evaluation of novel aminobisphosphonates possessing an in vivo antitumor activity through a γδ-T lymphocytes-mediated activation mechanism 154
Strong Bicyclic Guanidine Base-promoted Wittig and Horner-Wadsworth-Emmons Reactions 153
Synthesis of natural products via isoxazoles 152
A PLE-based resolution of cocaine, pseudococaine and 6-and 7-methoxylated cocaine analogues 152
Pterostilbene and 3'-hydroxypterostilbene are effective apoptosis-inducing agents in MDR and BCR-ABL-expressing leukemia cells. 150
3,6-Disubstituted 1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles: synthesis and evaluation for antimicrobial and antiviral activity. III. 149
ST1926, a novel and orally active retinoid-related molecule inducing apoptosis in myeloid leukemia cells: modulation of intracellular calcium homeostasis 149
Sintesi di derivati pirazolici e pirazolo[4,3-d]pirimidonici. Nota I 149
Cis-3, 4′, 5-Trimethoxy-3′-aminostilbene disrupts tumor vascular perfusion without damaging normal organ perfusion 148
Synthesis and antitumor activity of a new class of pyrazolo[4,3-e]pyrrolo[1,2-a][1,4]diazepinone analogs of pyrrolo[1,4]benzodiazepines (PBDs) 148
Pyrazole-Related Nucleosides. Synthesis and Antiviral/Antitumor Activity of Some Substituted Pyrazole and Pyrazolo[4,3-d]-1,2,3-triazin-4-one Nucleosides 146
5-Phenyl-isoxazole-3-carboxamides modulating Hsp90 with antitumoral activities 146
Synthesis of 1-phenyl-substituted 3-methyl-1H-pyrazolo[3,4-b]pyrazine-5,6-dicarboxylic acid diethyl esters. 146
Synthesis and reactivity of a stable precursor of 2-cyano-1,3-butadiene 145
Galangin increases the cytotoxic activity of imatinib mesylate in imatinib-sensitive and imatinib-resistant Bcr-Abl expressing leukemia cells 145
Analoghi eterociclici dell’acido retinoico (eteroretinoidi) come potenziali agenti “anti-aging”. 145
Facile synthesis of pyrazoles and pyrroles via thermolysis of tetrazolo[1,5-b]pyridazines, tetrazolo[1,5-a]pyrimidines and tetrazolo[1,5-a]pyridines 144
Inhibition of cell proliferation by a resveratrol analog in human pancreatic and breast cancer cells 144
A practical entry to C18-constrained-E-ring analogues of methyllycaconitine (MLA): a concise new stereoselective approach to 8-oxa-decahydrolsoquinolines accompanied by a simple microwaves-assisted synthesis of the succinimidobenzoate appendage of MLA 144
Two-carbon bridge substituted cocaines: Enantioselective synthesis, attribution of the absolute configuration and biological activity of novel 6- and 7-methoxylated cocaines 143
Facile synthesis of 2-nitroalkanols by Tetramethylguanidine (TMG)-catalyzed addition of primary nitroalkanes to aldehydes and alicyclic ketones 143
Isoxazole-mediated synthesis of geiparvarin and dihydrogeiparvarin 142
Facile access to 2'-O-acyl prodrugs of 1-(β-D-arabinofuranosyl)-5(E)-(2-bromovinyl)uracil (BVAraU) via regioselective esterase-catalyzed hydrolysis of 2',3',5'-triesters 142
Stereoselective synthesis of 8-aza-9,11-ethenoprostaglandin H1 141
Ethyl 5-substituted-3-isoxazole carboxvyates as starting materials for a convenient route to 3(2H )-furanones and 3(2H )-iminofuranes 140
A novel α-acrylate anion equivalent: A useful synthon for α-substituted acrylic esters 140
Mechanism of cell death induced by cis-3, 4′, 5-trimethoxy-3′-aminostilbene in ovarian cancer 140
Synthesis of an 11-Deoxy-8-azaprostaglandin E1 Intermediate 137
Regio - and enantioselective bioreduction of ethyl 2,4-dioxoalkanoates and γ-Keto-α-enamino esters with fermenting baker's yeast 137
Synthesis of 5-Hydroxy-2-oxotetrahydropyrroles 135
L’1,2-Dimetil-4-ossimino-3,5-pirazolidindione come attivatore nella sintesi peptidica 135
Synthesis and Prostaglandin-like Activity of 2-(trans-3-Hydroxy-1-octenyl)-3-indolheptanoic Acid 135
Synthesis and Antitumor Activity of a New Class of Pyrazolo[4,3-e]pyrrolo[1,2-a][1,4]diazepinone Analogs of Pyrrolo[1,4][2,1-c]benzodiazepines 134
The synergistic apoptotic effects of thiophenfurin, an inosine monophosphate dehydrogenase inhibitor, in combination with retinoids in HL60 cells 132
Pig liver esterase (PLE)-mediated resolution of N-substituted 4-benzoyloxy-3-carbomethoxypiperidines: a convenient preparation of 4-hydroxy- and 4-benzoyloxy-3-carbomethoxypiperidines in enantiomerically pure form 131
Brain receptor binding of analogues of gamma-aminobutyric acid (GABA) 130
Design, synthesis and antiproliferative activity of methyl 4-iodo-1-b-D-ribofuranosyl-pyrazole-3-carboxylate and related compounds 129
Structure-activity relationship studies of novel heteroretinoids: Induction of apoptosis in the HL-60 cell line by a novel isoxazole-containing heteroretinoid 129
Synthesis of 3-Methyl-6-phenylamino-substituted-1H-pyrazolo[4,3-d]pyrimidine-7(6H)-ones 129
Aryl and Heterocyclic Derivatives of Combretastatin A-4 Endowed with Anticancer Properties 128
5-Phenyl-isoxazole-3-carboxamides modulating HSP90 with antitumoral activities 128
Synthesis and Cytostatic Activity of Geiparvarin Analogues 128
Stilbene derivatives that are colchicine site microtubule inhibitors have antileukemic activity and minimal systemic toxicity 128
Totale 17.888
Categoria #
all - tutte 105.883
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 603
Totale 106.486


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/20211.371 0 0 0 0 0 233 65 246 49 280 297 201
2021/20221.798 67 126 127 106 184 86 71 82 84 93 161 611
2022/20231.649 166 107 57 203 301 254 40 157 211 12 82 59
2023/2024877 91 98 64 22 56 194 40 59 15 26 28 184
2024/20253.170 130 78 289 117 412 225 69 196 428 348 532 346
2025/20265.710 989 555 1.308 1.236 1.440 182 0 0 0 0 0 0
Totale 23.786