SIMONI, Daniele
 Distribuzione geografica
Continente #
NA - Nord America 10.932
EU - Europa 2.749
AS - Asia 2.233
SA - Sud America 13
Continente sconosciuto - Info sul continente non disponibili 11
AF - Africa 9
OC - Oceania 8
Totale 15.955
Nazione #
US - Stati Uniti d'America 10.903
CN - Cina 1.094
UA - Ucraina 692
DE - Germania 591
TR - Turchia 576
SG - Singapore 430
IT - Italia 400
GB - Regno Unito 351
SE - Svezia 293
FI - Finlandia 171
VN - Vietnam 56
FR - Francia 47
RU - Federazione Russa 43
PL - Polonia 40
BE - Belgio 37
NL - Olanda 33
CA - Canada 28
CZ - Repubblica Ceca 14
ID - Indonesia 13
IN - India 12
KR - Corea 11
JP - Giappone 10
EU - Europa 9
IR - Iran 9
AU - Australia 8
CL - Cile 7
IE - Irlanda 6
LT - Lituania 6
BR - Brasile 5
ES - Italia 5
IQ - Iraq 5
MA - Marocco 5
RO - Romania 5
TW - Taiwan 5
HK - Hong Kong 4
NO - Norvegia 4
CH - Svizzera 3
HU - Ungheria 3
A2 - ???statistics.table.value.countryCode.A2??? 2
DZ - Algeria 2
MY - Malesia 2
AF - Afghanistan, Repubblica islamica di 1
AT - Austria 1
BG - Bulgaria 1
BN - Brunei Darussalam 1
BW - Botswana 1
DK - Danimarca 1
GE - Georgia 1
GR - Grecia 1
JO - Giordania 1
MX - Messico 1
PE - Perù 1
PK - Pakistan 1
RS - Serbia 1
TH - Thailandia 1
TN - Tunisia 1
Totale 15.955
Città #
Fairfield 1.479
Woodbridge 1.298
Houston 902
Ashburn 805
Jacksonville 785
Chandler 722
Seattle 655
Ann Arbor 634
Wilmington 529
Cambridge 466
Singapore 343
Santa Clara 330
Izmir 250
Nanjing 245
Beijing 189
Princeton 159
Boardman 147
New York 139
San Diego 139
Addison 104
Shanghai 80
Shenyang 79
Nanchang 71
Hebei 59
Milan 58
Los Angeles 57
San Mateo 55
Dong Ket 54
Ferrara 54
Changsha 53
Tianjin 49
Bremen 42
Jinan 41
Warsaw 38
Brussels 37
London 36
Jiaxing 34
Falls Church 32
Munich 30
Helsinki 25
Philadelphia 25
Verona 24
Auburn Hills 21
Norwalk 21
Amsterdam 20
Guangzhou 20
Mountain View 19
Chicago 17
Zhengzhou 17
Dearborn 16
Kunming 16
Redwood City 16
Washington 16
Mcallen 15
Taizhou 15
Bologna 14
Frankfurt am Main 13
Hangzhou 13
Jakarta 12
Montréal 12
Indiana 11
Tappahannock 10
Augusta 9
Changchun 9
Des Moines 9
Monmouth Junction 9
Toronto 9
Düsseldorf 8
Haikou 8
Ningbo 8
Orange 8
Palermo 8
Redmond 8
Lanzhou 7
Olomouc 7
Brno 6
Dublin 6
Fuzhou 6
Kilburn 6
Leawood 6
Ottawa 6
Rome 6
Ardabil 5
Dallas 5
San Francisco 5
Taipei 5
Xian 5
Yellow Springs 5
Ferrara di Monte Baldo 4
Moscow 4
San Calogero 4
San Jose 4
Falkenstein 3
Madrid 3
Mangalore 3
New Haven 3
Padova 3
Paris 3
Pietro 3
Taiyuan 3
Totale 11.886
Nome #
1,2,4-triazoles. Improved synthesis of 5-substituited 4-amino-3mercato-(4H)-1,2,4 triazoles and a facile route to 3,6-disubstituited 1,24-triazolo[3,4b][1,3,4]thiadiazoles 267
1,5,7-Triazabicyclo[4.4.0]dec-1- ene (TBD), 7-Methyl-TBD (MTBD) and the polymer-supported TBD (P-TBD):Three efficient catalysts for the nitroaldol (Henry) reaction and for the addition of dialkyl phosphites to unsaturated systems. 230
Retinoic acid conjugates as potential antitumor agents: Synthesis and biological activity of conjugates with Ara-A, Ara-C, 3(2H)-furanone, and aniline mustard moieties 184
4,5,6,7-Tetrahydro-isoxazolo-[4,5-c]-pyridines as a new class of cytotoxic Hsp90 inhibitors 170
A facile, efficient synthesis of 2-substituted-4-hydroxy-2-cyclopenten-1-ones 166
Inhibition of activated STAT5 in Bcr/Abl expressing leukemia cells with new pimozide derivatives. 166
Hydropathic analysis and biological evaluation of stilbene derivatives as colchicine site microtubule inhibitors with anti-leukemic activity. 165
New TRAP1 and Hsp90 chaperone inhibitors with cationic components: Preliminary studies on mitochondrial targeting 161
Development of hemiasterlin derivatives as potential anticancer agents that inhibit tubulin polymerization and synergize with a stilbene tubulin inhibitor. 157
3,5-Disubstituted isoxazoles as a latent aldol moiety: application to the synthesis of (±)-[6]-gingerol. 154
Effects of Pimozide Derivatives on pSTAT5 in K562 Cells 153
A [3+2] nitrile oxide intermolecular cycloaddition approach to 4,5-dihydro-3(2H)-furanone and 3(2H)-furanone ring systems: application to the formal synthesis of (±)-ascofuranone and geiparvarin. 151
Novel iodoacetamido benzoheterocyclic derivatives with potent antileukemic activity are inhibitors of STAT5 phosphorylation 149
Geiparvarin analogs. 2. Synthesis and cytostatic activity of 5-(4-arylbutadienyl)-3(2H)-furanones and of N-substituted 3-(4-oxo-2-furanyl)-2-buten-2-yl carbamates. 147
3,5-Disubstituted isoxazoles as synthons for (±)-pyrenophorin and (±)-vermiculine synthesis. 147
Methyl 4-oxothiolane-3-carboxylate and methyl 2-methyl-4-oxothiolane-3- carboxylate anions as synthetic equivalents of α-acrylate and α-crotonate anions. Formal synthesis of integerrinecic acid 146
Stilbene 5c, a microtubule poison with vascular disrupting properties that induces multiple modes of growth arrest and cell death. 145
Geiparvarin Analogs. 3. Synthesis and cytostatic activity of 3(2H)-furanone and 4,5-dihydro-3(2H)-furanone congeners of geiparvarin, containing a geraniol-like fragment in the side chain 144
Ethyl 2,4-dioxoalkanoates as starting materials for a convenient route to 3(2H)-furanones and 3(2H)-furanimines 143
Lack of nucleophilic addition in the isoxazole and pyrazole diketone modified analogs of curcumin; implications for their antitumor and chemosensitizing activities. 143
Synthesis of 8-oxa analogues of norcocaine endowed with interesting cocaine-like activity 142
Arylamidonaphtalene sulfonate compounds as a novel class of heparanase inhibitors 140
A convenient synthesis of unsymmetrically substituted terphenyls of biologically active stilbenes via a double Suzuki cross-coupling protocol 140
Geiparvarin Analogs. 4.1. Synthesis and Cytostatic Activity of Geiparvarin Analogs Bearing a Carbamate Moiety or a Furocoumarin Fragment on the Alkenyl Side Chain 139
A [3 + 2] nitrile oxide cycloaddition approach to retinoids 137
Synthesis and biological evaluation of resveratrol and analogues as apoptosis-inducing agents 137
Hemiasterlin derivative (R)(S)(S)-BF65 and Akt inhibitor MK-2206 synergistically inhibit SKOV3 ovarian cancer cell growth 136
Development of water soluble derivatives of cis-3, 4', 5-trimethoxy-3'-aminostilbene for optimization and use in cancer therapy. 133
Synthesis of 2-(5-substituted isoxazol-3-yl)-4-oxo-3-thiazolidinyl alkanoic acids 132
A new nitrile oxide based synthesis of the antitumor agent geiparvarin 131
A novel hybrid drug between two potent anti-tubulin agents as a potential prolonged anticancer approach 130
Synthesis and pharmacology of 6-substituted benztropines: Discovery of novel dopamine uptake inhibitors possessing low binding affinity to the dopamine transporter 129
Novel A-ring and B-ring modified combretastatin A-4 (CA-4) analogues endowed with interesting cytotoxic activity 129
A new direct glycosylation of pyrimidine, pyrazole, imidazole and purine heterocycles via their N-tetrahydropyranyl (THP) derivatives 129
Total synthesis of (±)-isoclovene. 128
Synthesis of syn- and anti-tricyclo[4.1.0.02,4]heptan-5-ones and related compounds. 127
Heterocyclic and phenyl double-bond-locked combretastatin analogues possessing potent apoptosis-inducing activity in HL60 and in MDR cell lines 126
Synthesis of 6‐substituted‐4,5‐dihydro‐3(2H)‐pyridazinones 125
Synthesis of new pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine and 1,2,3-triazolo[4,5-e]1,2,4-triazolo[1,5-c]pyrimidine displaying potent and selective activity as A2a adenosine receptor antagonists 125
null 125
null 125
Synthesis and cytotoxic activity of 6-vinyl- and 6-ethynyluridine and 8-vinyl- and 8-ethynyladenosine 124
Cyclic guanidines: Synthesis of 4,6,7,8‐tetrahydro‐1H‐imidazo[1,2‐a]pyrazolo[3,4‐d]pyrimidin‐7‐ones and 1,4,6,7,8,9‐hexahydropyrazolo[3′,4′:4,5]pyrimido[2,1‐c] [1,2,4]triazin‐7‐ones 124
Preparation of 3,4-dihydroxy-1-benzeneethanol: a reinvestigation 123
Stereospecific nitromethane conjugate addition to 4-oxygenated 2-substituted cyclopent-2-enones: a simple approach to prostaglandins. 123
Novel terphenyls and 3,5-diaryl isoxazole derivatives endowed with growth supporting and antiapoptotic properties 123
Pyrazole-Related Nucleosides. Synthesis and Antiviral/Antitumor Activity of Some Substituted Pyrazole and Pyrazolo[4,3-d]-1,2,3-triazin-4-one Nucleosides 122
Effects of two-carbon bridge region methoxylation of benztropine: discovery of novel chiral ligands for the dopamine transporter 122
ST1926, a novel and orally active retinoid-related molecule inducing apoptosis in myeloid leukemia cells: modulation of intracellular calcium homeostasis 120
Sintesi di derivati pirazolici e pirazolo[4,3-d]pirimidonici. Nota I 120
A one-pot glycosylation of tetrahydropyranyl (THP) ether intermediates 119
Studies on the apoptotic activity of natural and synthetic retinoids: Discovery of a new class of synthetic terphenyls that potently support cell growth and inhibit apoptosis in neuronal and HL-60 cells 119
Curcumin as a possible lead compound against hormone-independent, multidrug-resistant breast cancer 115
Heterocycle-containing retinoids. Discovery of a novel isoxazole arotinoid possessing potent apoptotic activity in multidrug and drug-induced apoptosis-resistant cells. 115
Design, synthesis and biological evaluation of novel stilbene-based antitumor agents 114
Cis-3, 4′, 5-Trimethoxy-3′-aminostilbene disrupts tumor vascular perfusion without damaging normal organ perfusion 113
Concise enantioselective synthesis and attribution of the absolute configuration of two-carbon bridge methoxylated cocaines and pseudococaines 113
Synthesis of natural products via isoxazoles. 112
Synthesis and antitumor activity of a new class of pyrazolo[4,3-e]pyrrolo[1,2-a][1,4]diazepinone analogs of pyrrolo[1,4]benzodiazepines (PBDs) 112
Mechanism of cell death induced by cis-3, 4′, 5-trimethoxy-3′-aminostilbene in ovarian cancer 111
Sintesi di derivati pirazolici e pirazolo[4,3-d]pirimidonici. Nota II 110
Stereoselective synthesis of 8-aza-9,11-ethenoprostaglandin H1 110
Facile access to 2'-O-acyl prodrugs of 1-(β-D-arabinofuranosyl)-5(E)-(2-bromovinyl)uracil (BVAraU) via regioselective esterase-catalyzed hydrolysis of 2',3',5'-triesters 109
Strong Bicyclic Guanidine Base-promoted Wittig and Horner-Wadsworth-Emmons Reactions 109
Derivati isossazolici come induttori di emoglobina fetale in precursori eritroidi derivati da pazienti beta-talassemici 109
Synthesis and reactivity of a stable precursor of 2-cyano-1,3-butadiene 108
Galangin increases the cytotoxic activity of imatinib mesylate in imatinib-sensitive and imatinib-resistant Bcr-Abl expressing leukemia cells 108
Synthesis of 1-phenyl-substituted 3-methyl-1H-pyrazolo[3,4-b]pyrazine-5,6-dicarboxylic acid diethyl esters. 108
Antitumor effects of new synthetic isoxazole derivatives 108
Novel combretastatin analogues endowed with antitumor activity 108
The antitumor activities of curcumin and of its isoxazole analogue are not affected by multiple gene expression changes in an MDR model of the MCF-7 breast cancer cell line: Analysis of the possible molecular basis 106
Facile synthesis of 2-nitroalkanols by Tetramethylguanidine (TMG)-catalyzed addition of primary nitroalkanes to aldehydes and alicyclic ketones 106
Facile synthesis of pyrazoles and pyrroles via thermolysis of tetrazolo[1,5-b]pyridazines, tetrazolo[1,5-a]pyrimidines and tetrazolo[1,5-a]pyridines 105
Synthesis of an 11-Deoxy-8-azaprostaglandin E1 Intermediate 104
Two-carbon bridge substituted cocaines: enantioselective synthesis, attribution of the absolute configuration and biological activity of novel 6- and 7-methoxylated cocaines. 104
Structure-activity relationship studies of novel heteroretinoids: Induction of apoptosis in the HL-60 cell line by a novel isoxazole-containing heteroretinoid 103
Synthesis of 5-Hydroxy-2-oxotetrahydropyrroles 103
Antitumor effects of curcumin and structurally β-diketone modified analogs on multidrug resistant cancer cells 103
Enantioselective deprotonation of the 8-oxabicyclo[3.2.1]octan-3-one: Synthesis of 8-oxa-norcocaines and 8-oxa-pseudonorcocaines 102
Synthesis and Antitumor Activity of a New Class of Pyrazolo[4,3-e]pyrrolo[1,2-a][1,4]diazepinone Analogs of Pyrrolo[1,4][2,1-c]benzodiazepines 102
Pterostilbene and 3'-hydroxypterostilbene are effective apoptosis-inducing agents in MDR and BCR-ABL-expressing leukemia cells. 101
Synthesis of new 2,2 '-disubstituted 5,5 '-dimethyl-4,4 '-bitriazoles and 2-(4-triazolyl)quinoxalines 100
The synergistic apoptotic effects of thiophenfurin, an inosine monophosphate dehydrogenase inhibitor, in combination with retinoids in HL60 cells 100
Inhibition of cell proliferation by a resveratrol analog in human pancreatic and breast cancer cells 99
Anticancer drugs targeting the apoptotic pathway 98
Design, synthesis and antiproliferative activity of methyl 4-iodo-1-b-D-ribofuranosyl-pyrazole-3-carboxylate and related compounds 97
Stilbene derivatives that are colchicine site microtubule inhibitors have antileukemic activity and minimal systemic toxicity 97
Synthesis of 3-Methyl-6-phenylamino-substituted-1H-pyrazolo[4,3-d]pyrimidine-7(6H)-ones 96
Synthesis and Cytostatic Activity of Geiparvarin Analogues 95
Effects of chemically modified tetracyclines (CMTs) in sensitive, multidrug resistant and apoptosis resistant leukaemia cell lines 94
Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells 94
Regio - and enantioselective bioreduction of ethyl 2,4-dioxoalkanoates and γ-Keto-α-enamino esters with fermenting baker's yeast 94
A PLE-based resolution of cocaine, pseudococaine and 6-and 7-methoxylated cocaine analogues 94
Asymmetric synthesis of a β-ketol moiety via 3,5-disubstituted isoxazoles: Application to (+)-(S)-[6]-gingerol 93
3,6-Disubstituted 1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles: synthesis and evaluation for antimicrobial and antiviral activity. III. 90
L’1,2-Dimetil-4-ossimino-3,5-pirazolidindione come attivatore nella sintesi peptidica 90
Synthesis and evaluation of the antifungal activity of a new class of N-acylureas 89
Isoxazole-mediated synthesis of geiparvarin and dihydrogeiparvarin 88
Tyrosine kinase ihibitors for the treatment of chronic myeloid leukemia 88
Pig liver esterase (PLE)-mediated resolution of N-substituted 4-benzoyloxy-3-carbomethoxypiperidines: a convenient preparation of 4-hydroxy- and 4-benzoyloxy-3-carbomethoxypiperidines in enantiomerically pure form 87
Totale 12.306
Categoria #
all - tutte 69.581
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 375
Totale 69.956


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20202.117 0 0 0 0 234 392 296 340 279 388 126 62
2020/20212.213 181 225 130 228 65 235 65 249 49 283 300 203
2021/20221.818 67 127 129 107 186 88 71 83 86 94 162 618
2022/20231.678 169 109 57 207 307 261 40 159 215 12 82 60
2023/2024891 92 100 64 22 57 196 42 63 15 27 28 185
2024/20251.042 131 83 292 120 416 0 0 0 0 0 0 0
Totale 16.136