A new synthesis of geiparvarin and its dihydroderivative two naturally occurring antitumor agents, possessing the 3(2H)-furanone ring system central structural feature, is described. The synthetic design is based on the use of suitably substituted isoxazole derivatives, the heterocyclic ring acting as masked 1,3-diketone moiety.

Isoxazole-mediated synthesis of geiparvarin and dihydrogeiparvarin

BARALDI, Pier Giovanni
Primo
;
BARCO, Achille
Secondo
;
BENETTI, Simonetta;CASOLARI, Alberto;MANFREDINI, Stefano;POLLINI, Gian Piero
Penultimo
;
SIMONI, Daniele
Ultimo
1988

Abstract

A new synthesis of geiparvarin and its dihydroderivative two naturally occurring antitumor agents, possessing the 3(2H)-furanone ring system central structural feature, is described. The synthetic design is based on the use of suitably substituted isoxazole derivatives, the heterocyclic ring acting as masked 1,3-diketone moiety.
1988
Baraldi, Pier Giovanni; Barco, Achille; Benetti, Simonetta; Casolari, Alberto; Manfredini, Stefano; Pollini, Gian Piero; Simoni, Daniele
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/460421
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