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Factors associated with blood cord unit bankability: an analysis of a 15-year-long case series

Blood banking is a long and complex process requiring an accurate screening of potential donors and high-quality control systems. Previous studies in literature investigated factors potentially determining a higher cell levels with the aim of optimizing donors' selection and improving banking process. This study aims to identify factors associated with the concentration of stem cells in umbilical cord blood, so increasing the probability of bankability, focusing on the possible implications i...

Planck 2018 constraints on anisotropic birefringence and its cross-correlation with CMB anisotropy

Parity-violating extensions of standard electromagnetism produce cosmic birefringence, the in vacuo rotation of the linear polarisation direction of a photon during propagation. We employ Planck 2018 CMB polarised data to constrain anisotropic birefringence, modeled by its angular power spectrum Cℓα α, and the cross-correlation with CMB temperature maps, Cℓα T, at scales larger than ∼15 degrees. We present joint limits on the scale invariant quantity, Aα α ≡ ℓ (ℓ +1) Cℓα α / 2 π, and on the a...

Pragmatic representations of self- and others’ action in the monkey putamen

Social coordination in primates relies on parieto-frontal networks encoding self- and others' actions. These areas send convergent projections to the putamen, but its role in representing self- and others' actions remains unknown. We recorded neuronal activity from anatomically characterized putamen regions of two male macaques during a Mutual Action Task (MAT), where a monkey and a human took turns grasping a multi-affordance object based on sensory cues. Cortico-striatal synaptic input, ind...

Liver transplantation in mitochondrial neurogastrointestinal encephalomyopathy (MNGIE): clinical long-term follow-up and pathogenic implications

We report the longest follow-up of clinical and biochemical features of two previously reported adult mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) patients treated with liver transplantation (LT), adding information on a third, recently transplanted, patient. All three patients overcame the early post-operative period and tolerated immunosuppressive therapy. Plasma nucleoside levels dramatically decreased, with evidence of clinical improvement of ambulation and neuropathy. Co...

Sex-related pharmacokinetic and pharmacological responses to 4F-furanylfentanyl

Background: Novel synthetic opioids (NSOs), including a variety of fentanyl analogs (FAs) and emerging non-fentanyl compounds, have increasingly been implicated in overdose fatalities worldwide. Among these, 4-fluorofuranylfentanyl (4F-FUF) is a potent FA with limited in vivo pharmacotoxicological characterization. In this study, we aimed to i. evaluate the pharmacotoxicological effects of 4F-FUF in male and female mice, ii. determine its pharmacokinetic profile in plasma and tissues of...

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