Geiparvarin 1 has been synthesized utilizing the 3,5-disubstituted isoxazole 8 as protected synthon for the 3(2h)furanone system, the desired α′-hydroxy-1,3-diketone precursor being eventually revealed by Mo(CO)6 promoted reductive cleavage.
A new nitrile oxide based synthesis of the antitumor agent geiparvarin
BARALDI, Pier Giovanni;BENETTI, Simonetta;MANFREDINI, Stefano;POLLINI, Gian Piero;SIMONI, Daniele
1985
Abstract
Geiparvarin 1 has been synthesized utilizing the 3,5-disubstituted isoxazole 8 as protected synthon for the 3(2h)furanone system, the desired α′-hydroxy-1,3-diketone precursor being eventually revealed by Mo(CO)6 promoted reductive cleavage.File in questo prodotto:
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