Nitrosation of pyrazoles I (R = H, X = H, 2-, 3-, 4-Cl, 4-Me) by EtONO in 10% HCl gave I (R = NO) which were cyclocondensed with EtO2CC≡CCO2Et in refluxing PhMe to give 61-70% pyrazolopyrazines II via the probable intermediate III.
Synthesis of 1-phenyl-substituted 3-methyl-1H-pyrazolo[3,4-b]pyrazine-5,6-dicarboxylic acid diethyl esters.
BARALDI, Pier Giovanni;SIMONI, Daniele;PERIOTTO, Vittorio;MANFREDINI, Stefano;GUARNERI, Mario
1984
Abstract
Nitrosation of pyrazoles I (R = H, X = H, 2-, 3-, 4-Cl, 4-Me) by EtONO in 10% HCl gave I (R = NO) which were cyclocondensed with EtO2CC≡CCO2Et in refluxing PhMe to give 61-70% pyrazolopyrazines II via the probable intermediate III.File in questo prodotto:
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