TRAPELLA, Claudio
 Distribuzione geografica
Continente #
NA - Nord America 15.011
AS - Asia 6.502
EU - Europa 5.032
SA - Sud America 1.010
AF - Africa 107
OC - Oceania 11
Continente sconosciuto - Info sul continente non disponibili 8
Totale 27.681
Nazione #
US - Stati Uniti d'America 14.674
SG - Singapore 2.660
CN - Cina 1.848
IT - Italia 1.245
DE - Germania 1.024
BR - Brasile 842
HK - Hong Kong 602
GB - Regno Unito 556
UA - Ucraina 513
VN - Vietnam 511
FI - Finlandia 413
TR - Turchia 359
PL - Polonia 306
SE - Svezia 266
RU - Federazione Russa 180
CA - Canada 179
MX - Messico 124
ID - Indonesia 122
FR - Francia 104
BE - Belgio 100
IN - India 100
JP - Giappone 86
NL - Olanda 76
BD - Bangladesh 56
AR - Argentina 55
ZA - Sudafrica 52
ES - Italia 47
LT - Lituania 45
AT - Austria 40
CZ - Repubblica Ceca 38
IQ - Iraq 28
EC - Ecuador 23
VE - Venezuela 20
CO - Colombia 17
CL - Cile 16
IE - Irlanda 16
IR - Iran 16
MA - Marocco 14
PE - Perù 14
KR - Corea 13
NO - Norvegia 13
PK - Pakistan 13
BG - Bulgaria 12
PY - Paraguay 11
SA - Arabia Saudita 11
AU - Australia 9
NP - Nepal 9
UZ - Uzbekistan 9
JO - Giordania 8
DZ - Algeria 7
RO - Romania 7
TN - Tunisia 7
TW - Taiwan 7
UY - Uruguay 7
DO - Repubblica Dominicana 6
EG - Egitto 6
JM - Giamaica 6
AE - Emirati Arabi Uniti 5
CR - Costa Rica 5
KZ - Kazakistan 5
NG - Nigeria 5
CH - Svizzera 4
DK - Danimarca 4
EU - Europa 4
HN - Honduras 4
IL - Israele 4
KE - Kenya 4
LV - Lettonia 4
MY - Malesia 4
PA - Panama 4
TH - Thailandia 4
XK - ???statistics.table.value.countryCode.XK??? 4
BO - Bolivia 3
GT - Guatemala 3
KW - Kuwait 3
PT - Portogallo 3
SN - Senegal 3
TT - Trinidad e Tobago 3
AM - Armenia 2
AO - Angola 2
BH - Bahrain 2
BN - Brunei Darussalam 2
CI - Costa d'Avorio 2
EE - Estonia 2
ET - Etiopia 2
GR - Grecia 2
KG - Kirghizistan 2
LU - Lussemburgo 2
PH - Filippine 2
RS - Serbia 2
SM - San Marino 2
SY - Repubblica araba siriana 2
TJ - Tagikistan 2
AZ - Azerbaigian 1
CV - Capo Verde 1
CY - Cipro 1
DM - Dominica 1
GA - Gabon 1
GE - Georgia 1
GI - Gibilterra 1
Totale 27.667
Città #
Dallas 1.731
Singapore 1.568
Ashburn 1.552
Fairfield 1.351
Woodbridge 1.219
Ann Arbor 801
Houston 789
Beijing 712
Chandler 672
Santa Clara 618
Hong Kong 593
Seattle 585
Jacksonville 556
Munich 526
Wilmington 524
Cambridge 468
Ferrara 454
Warsaw 297
New York 250
Los Angeles 237
Helsinki 207
Izmir 199
Nanjing 174
Princeton 154
Milan 141
Ho Chi Minh City 138
Shanghai 128
Boardman 115
Dong Ket 106
San Diego 101
Jakarta 99
Brussels 95
Hanoi 93
London 89
Mexico City 85
São Paulo 85
Turku 78
Tokyo 71
Bologna 68
Dearborn 60
Buffalo 58
Hefei 58
Shenyang 57
The Dalles 57
Montreal 53
Orem 52
Nanchang 51
Toronto 51
Poplar 49
Chicago 48
Brooklyn 47
Addison 46
Stockholm 45
Tianjin 45
Bremen 43
Frankfurt am Main 43
Moscow 42
Denver 41
Rio de Janeiro 41
Atlanta 39
Chennai 38
Johannesburg 37
Falls Church 36
Amsterdam 35
Redwood City 35
Jiaxing 33
Rome 33
San Jose 33
Hebei 32
Auburn Hills 31
Falkenstein 31
Boston 30
San Francisco 30
Manchester 29
Mcallen 26
Norwalk 26
Mountain View 25
Phoenix 25
Changsha 24
San Mateo 24
Washington 24
Belo Horizonte 21
Montréal 20
Charlotte 19
Brno 18
Haiphong 18
Zhengzhou 18
Council Bluffs 17
Curitiba 17
Da Nang 17
Ferrara di Monte Baldo 17
Jyväskylä 17
Nuremberg 17
Columbus 16
Jinan 16
Olomouc 16
Ottawa 16
Philadelphia 16
Porto Alegre 16
Vienna 16
Totale 19.720
Nome #
1,3,8-Triazaspiro compounds and their use as medicaments for the treatment of reperfusion injury. 1.038
1,3,8-Triazaspiro[4.5]decane Derivatives Inhibit Permeability Transition Pores through a FO-ATP Synthase c Subunit Glu119-Independent Mechanism That Prevents Oligomycin A-Related Side Effects 954
1‐cyclohexyl‐x‐methoxybenzene derivatives, novel psychoactive substances seized on the internet market. Synthesis and in vivo pharmacological studies in mice 372
Effect of the novel synthetic cannabinoids AKB48 and 5F-AKB48 on “tetrad”, sensorimotor, neurological and neurochemical responses in mice. In vitro and in vivo pharmacological studies 349
A linear allergic contact dermatitis to p-tert-butylphenol formaldehyde resin sectorially present in a neoprene orthopedic brace: role of spectroscopy 314
1,4-Dithiane-2,5-diol: An Attractive Platform for the Synthesis of Sulfur-Containing Functionalized Heterocycles 301
Pharmacological characterization of the nociceptin/orphanin FQ receptor antagonist SB-612111 [(-)-cis-1-methyl-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-6,7,8 ,9-tetrahydro-5H-benzocyclohepten-5-ol]: In vivo studies 278
Design, synthesis and biological characterization of novel mitochondria targeted dichloroacetate-loaded compounds with antileukemic activity 262
A diastereoselective synthesis of Cebranopadol, a novel analgesic showing NOP/mu mixed agonism 260
Synthetic cannabinoid JWH-018 and its halogenated derivatives JWH-018-Cl and JWH-018-Br impair Novel Object Recognition in mice: Behavioral, electrophysiological and neurochemical evidence 255
A novel and facile synthesis of tetra branched derivatives of nociceptin/orphanin FQ 254
Discovery of Novel 1,3,8-Triazaspiro[4.5]decane Derivatives That Target the c Subunit of F1/FO-Adenosine Triphosphate (ATP) Synthase for the Treatment of Reperfusion Damage in Myocardial Infarction 252
Novel halogenated derivates of JWH-018: Behavioral and binding studies in mice 247
Design and synthesis of99mTcN-labeled dextran-mannose derivatives for sentinel lymph node detection 244
Effect of JWH-250, JWH-073 and their interaction on “tetrad”, sensorimotor, neurological and neurochemical responses in mice 239
Expeditious Synthesis and Biological Characterization of Enantio-Enriched (-)-Nutlin-3 232
C-terminal constrained phenylalanine as a pharmacophoric unit in peptide-based proteasome inhibitors 219
New TRAP1 and Hsp90 chaperone inhibitors with cationic components: Preliminary studies on mitochondrial targeting 218
Conjugation of LasR Quorum-Sensing Inhibitors with Ciprofloxacin Decreases the Antibiotic Tolerance of P-aeruginosa Clinical Strains 214
null 214
Neuropeptide S reduces mouse aggressiveness in the resident/intruder test through selective activation of the neuropeptide S receptor 210
Tryptophan replacement in the nociceptin/orphanin FQ receptor ligand Ac-RYYRWK-NH2 208
N- and C-terminal modifications of nociceptin/orphanin FQ generate highly potent NOP receptor ligands 207
Structure activity studies of nociceptin/orphanin FQ(1–13)-NH2 derivatives modified in position 5 207
Structure-activity studies on the nociceptin/orphanin FQ receptor antagonist 1-benzyl-N-{3-[spiroisobenzofuran-1(3H),4′-piperidin-1-yl]propyl} pyrrolidine-2-carboxamide 206
[D-Pen(p-tBuBzl)5]NPS, a novel ligand for the neuropeptide S receptor: structure activity and pharmacological studies 205
Identification of an achiral analogue of J-113397 as potent nociceptin/orphanin FQ receptor antagonist 202
HelixComplex snail mucus exhibits pro-survival, proliferative and pro-migration effects on mammalian fibroblasts 202
In vitro and in vivo pharmaco-dynamic study of the novel fentanyl derivatives: Acrylfentanyl, Ocfentanyl and Furanylfentanyl 201
Conformation-activity relationship of neuropeptide S and some structural mutants: Helicity affects their interaction with the receptor 201
Structure-and conformation-Activity studies of nociceptin/orphanin FQ receptor dimeric ligands 199
Naphthoquinone amino acid derivatives, synthesis and biological activity as proteasome inhibitors 198
Nocistatin inhibits 5-hydroxytryptamine release in the mouse neocortex via presynaptic G i/o protein linked pathways 196
Further studies on the pharmacological features of the nociceptin/orphanin FQ receptor ligand ZP120 196
Pharmacological profile of nociceptin/orphanin FQ receptors regulating 5-hydroxytryptamine release in the mouse neocortex 194
A new synthetic approach to 1-[(3R,4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidyl]-3-ethyl-1,3-dihydro-benzimidazol-2-one (J-113397), the first non-peptide ORL-1 receptor antagonist 192
Dopamine-nociceptin/orphanin FQ interactions in the substantia nigra reticulata of hemiparkinsonian rats: Involvement of D2/D3 receptors and impact on nigro-thalamic neurons and motor activity 192
Sviluppo di un Sistema combinato a filiera controllata per l’allevamento, l’estrazione, la caratterizzazione e la sanificazione del secreto di chiocciola 190
Physicochemical stability of cabazitaxel and docetaxel solutions 190
Synthesis and biological activity of human neuropeptide S analogues modified in position 2 189
Endogenous nociceptin/orphanin FQ signalling produces opposite spinal antinociceptive and supraspinal pronociceptive effects in the mouse formalin test: Pharmacological and genetic evidences 188
C subunit of F1/FO-ATP synthase as target for preventing the detrimental effect of myocardial ischemia/reperfusion injury 186
Anxiolytic- and antidepressant-like activities of H-Dmt-Tic-NH-CH(CH2-COOH)-Bid (UFP-512), a novel selective delta opioid receptor agonist 185
JWH-018 impairs sensorimotor functions in mice 185
Synthesis and proteasome inhibition of N-allyl vinyl ester-based peptides 185
Pharmacological characterization of the nociceptin/orphanin FQ receptor non peptide antagonist Compound 24 184
Letter to the Editor: Antimicrobial properties of mucus from the brown garden snail Helix aspersa 183
Pharmacological characterization of the nociceptin/orphanin FQ receptor antagonist SB-612111 [(-)-cis-1-methyl-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl] methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol]: In vitro studies 183
Helix aspersa muller mucus (Helixcomplex ®) interferes with Herpes simplex 1 virus infection 182
In vitro pharmacological characterization of a novel unbiased NOP receptor-selective nonpeptide agonist AT-403 180
Further studies on lead compounds containing the opioid pharmacophore Dmt-Tic. 178
Further studies at neuropeptide S position 5: Discovery of novel neuropeptide S receptor antagonists 178
Discovery of novel fetal hemoglobin inducers for β-thalassemia by small chemical library screening 178
Studies of C-terminal naphthoquinone dipeptides as 20S proteasome inhibitors 177
N-carbamidoyl-4-((3-ethyl-2,4,4-trimethylcyclohexyl)methyl)benzamide enhances staurosporine cytotoxic effects likely inhibiting the protective action of Magmas toward cell apoptosis 177
Pharmacological profile of nociceptin/orphanin FQ receptors interacting with G-proteins and β-arrestins 2 175
Antinociceptive action of NOP and opioid receptor agonists in the mouse orofacial formalin test 175
Biochemically Controlled Release of Dexamethasone Covalently Bound to PEDOT 175
Synthesis and activity of isoxazoline vinyl ester pseudopeptides as proteasome inhibitors 174
Intrathecal administration of nociceptin/orphanin FQ receptor agonists in rats: A strategy to relieve chemotherapy-induced neuropathic hypersensitivity 172
Neurological, sensorimotor and cardiorespiratory alterations induced by methoxetamine, ketamine and phencyclidine in mice 171
Synthesis and biological activity of nociceptin/orphanin FQ analogues substituted in position 7 or 11 with C alpha,alpha-dialkylated amino acids 171
The nociceptin/orphanin FQ receptor antagonist J-113397 and L-DOPA additively attenuate experimental parkinsonism through overinhibition of the nigrothalamic pathway 170
Neuropeptide S receptor ligands: a patent review (2005-2016) 170
Recent advances in the stereoselective synthesis of trans-3,4- disubstituted-piperidines: applications to (-)paroxetine 169
Structure-activity study at positions 3 and 4 of human neuropeptide S. 168
P3 and P4 position analysis of vinyl ester pseudopeptide proteasome inhibitors 164
Synthesis and Biological Activity of Human Neuropeptide S Analogues Modified in Position 5: Identification of Potent and Pure Neuropeptide S Receptor Antagonists 164
A Convenient Route to Enantiomerically Pure 2-Substituted Methyl Glycerate Derivatives 164
HelixComplex snail mucus as a potential technology against O3 induced skin damage 162
Structure-activity relationship study of position 4 in the urotensin-II receptor ligand U-II(4-11) 161
Mastering chiral substituted 2-oxopiperazines 161
Synthesis and biological evaluation of new vinyl ester pseudotripeptide proteasome inhibitors 160
The Importance of Ligand-Receptor Conformational Pairs in Stabilization: Spotlight on the N/OFQ G Protein-Coupled Receptor 160
Pharmacological profile of NOP receptors coupled with calcium signaling via the chimeric protein Gαqi5 159
In vitro and in vivo pharmacological characterization of the novel neuropeptide S receptor ligands QA1 and PI1 159
Proteomic approach to the identification of early phase biomarker for anticancer peptides targeting thefolate pathway 159
A new amido-phosphine of dichloroacetic acid as an active ligand for metals of pharmaceutical interest. Synthesis, characterization and tests of antiproliferative and pro-apoptotic activity 159
Novel halogenated synthetic cannabinoids impair sensorimotor functions in mice 158
New opioid designed multiple ligand from Dmt-Tic and morphinan pharmacophores 157
Synthesis and separation of the enantiomers of the neuropeptide S receptor antagonist (9R/S)-3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic acid 4-fluoro-benzylamide (SHA 68). 156
Pseudomonas aeruginosa quorum sensing molecule N-(3-oxododecanoyl)-L-homoserine-lactone induces HLA-G expression in human immune cells 156
Anxiolytic and antidepressant-like activities of UFP-512, a novel selective delta opiold receptor agonist 155
Structure-activity relationship study on Tyr9 of urotensin-II(4-11): Identification of a partial agonist of the UT receptor 152
NOP receptor pharmacological profile – A dynamic mass redistribution study 152
Enzymatic esterification as potential strategy to enhance the sorbic acid behavior as food and beverage preservative 151
Development and characterisation of novel fentanyl-delta opioid receptor antagonist based bivalent ligands 149
Role of benzimidazole (Bid) in the d-opioid agonist pseudopeptide H-Dmt-Tic-NH-CH2-Bid (UFP-502) 149
Pharmacological characterization of cebranopadol a novel analgesic acting as mixed nociceptin/orphanin FQ and opioid receptor agonist 149
Design of Nanosystems for the Delivery of Quorum Sensing Inhibitors: A Preliminary Study 149
Glyceric Prodrug of Ursodeoxycholic Acid (UDCA): Novozym 435-Catalyzed Synthesis of UDCA-Monoglyceride 149
6-N,N-dimethylamino-2,3-naphthalimide: A new environment-sensitive fluorescent probe in delta- and mu-selective opioid peptides 147
Chemoenzymatic Stereodivergent Synthesis of All the Possible Stereoisomers of the 2,3-Dimethylglyceric Acid Ethyl Ester 146
A Cationic Contrast Agent in X-ray Imaging of Articular Cartilage: Pre-Clinical Evaluation of Diffusion and Attenuation Properties 145
Neuropeptide S inhibits release of 5-HT and glycine in mouse amygdala and frontal/prefrontal cortex through activation of the neuropeptide S receptor 145
Helix aspersa muller mucus (Helixcomplex ®) p41 protein prevents Pseudomonas aeruginosa growth and promotes mammalian bronchial epithelial cell proliferation 145
Structure-activity studies on neuropeptide S - Identification of the amino acid residues crucial for receptor activation 143
JWH-018 and its N-pentyl-halogenated derivates impair sensory motor functions in mice. 142
Xylitol as a Hydrophilization Moiety for a Biocatalytically Synthesized Ibuprofen Prodrug 138
Effect of lysine at C-terminus of the Dmt-Tic opioid pharmacophore 136
Totale 20.521
Categoria #
all - tutte 125.224
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 595
Totale 125.819


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/20211.717 0 0 0 0 0 204 169 304 116 400 284 240
2021/20221.780 107 169 150 104 138 68 123 99 75 134 165 448
2022/20231.779 180 156 70 207 254 202 110 158 227 18 111 86
2023/20241.279 90 121 90 37 92 227 74 109 38 49 44 308
2024/20254.834 112 123 405 256 487 459 281 306 861 388 632 524
2025/20268.676 1.427 835 2.202 1.576 1.824 812 0 0 0 0 0 0
Totale 28.054