The synthesis and the preliminary biological evaluation of the first high affinity radioligand antagonist for the human A3 adenosine receptor, named [3H]-MRE 3008-F20 are reported. [3H]-MRE 3008-20 bound human A3 receptors expressed in CHO cells with K(D) and B(max) value of 0.82 ± 0.08 nM and 297 ± 28 fmol/mg of protein, respectively. [3H]-MRE 3008-F20 represents a useful tool for a further characterization of A3 adenosine receptor subtype. (C) 2000 Elsevier Science Ltd. All rights reserved.

Synthesis and preliminary biological evaluation of [H-3]-MRE 3008-F20: the first high affinity radioligand antagonist for the human A(3) adenosine receptors

BARALDI, Pier Giovanni;CACCIARI, Barbara;ROMAGNOLI, Romeo;VARANI, Katia;MERIGHI, Stefania;GESSI, Stefania;
2000

Abstract

The synthesis and the preliminary biological evaluation of the first high affinity radioligand antagonist for the human A3 adenosine receptor, named [3H]-MRE 3008-F20 are reported. [3H]-MRE 3008-20 bound human A3 receptors expressed in CHO cells with K(D) and B(max) value of 0.82 ± 0.08 nM and 297 ± 28 fmol/mg of protein, respectively. [3H]-MRE 3008-F20 represents a useful tool for a further characterization of A3 adenosine receptor subtype. (C) 2000 Elsevier Science Ltd. All rights reserved.
2000
Baraldi, Pier Giovanni; Cacciari, Barbara; Romagnoli, Romeo; Varani, Katia; Merighi, Stefania; Gessi, Stefania; Borea, P. A.; Leung, E.; Hickey, S. L....espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/517091
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