A formal synthesis of (±)-forskolin 1 has been accomplished utilizing 1,3-dipolar nitrile oxide cycloaddition chemistry either for an alternative and convenient preparation of the key enedione starting building block 3 as well as for the introduction of the suitably functionalized carbon framework required for assembling the pyranone unit. The synthetic sequence constitues a new synthetic route to the natural target since the enone 29 has been previously converted to (±)forskolin.
A formal total synthesis (±)-forskolin through [3+2] nitrile oxide cycloaddition chemistry
BARCO, AchillePrimo
;BENETTI, Simonetta
Secondo
;SPALLUTO G.;CASOLARI, Alberto;POLLINI, Gian Piero;ZANIRATO, VinicioPenultimo
;BARALDI, Pier GiovanniUltimo
1991
Abstract
A formal synthesis of (±)-forskolin 1 has been accomplished utilizing 1,3-dipolar nitrile oxide cycloaddition chemistry either for an alternative and convenient preparation of the key enedione starting building block 3 as well as for the introduction of the suitably functionalized carbon framework required for assembling the pyranone unit. The synthetic sequence constitues a new synthetic route to the natural target since the enone 29 has been previously converted to (±)forskolin.File in questo prodotto:
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Farmaco 1991, 46(11), 1281-1295.pdf
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