A new formal synthesis of the potent neurotoxin,Acromelic acid A, has been accomplished by a tandem Michael reaction involving a 2-nitro-1,3-diene incorporated into a dihydropyridone nucleus as electrophilic alkene and an unsaturated glutamic ester derivative prepared from D-serine as a tool for the stereoselective construction of the 2,3,4-trisubstitued pyrrolidine ring sistem.
Enantioselective formal synthesis of Acromelic acid A via tandem Michael reaction methodoligy
BENETTI, Simonetta;
1993
Abstract
A new formal synthesis of the potent neurotoxin,Acromelic acid A, has been accomplished by a tandem Michael reaction involving a 2-nitro-1,3-diene incorporated into a dihydropyridone nucleus as electrophilic alkene and an unsaturated glutamic ester derivative prepared from D-serine as a tool for the stereoselective construction of the 2,3,4-trisubstitued pyrrolidine ring sistem.File in questo prodotto:
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