Among the symptoms of SARS-CoV-2, follicular conjunctivitis has become relevant. The conjunctiva acts as an open lymph node, reacting to the viral antigen that binds the epithelial cells, forming follicles of B cells with activated T cells and NK cells on its surface, which, in turn, talk to monocyte-derived inflammatory infected macrophages. Here, the NLRP3 inflammasome is a major driver in releasing pro-inflammatory factors such as IL-6 and caspase-1, leading to follicular conjunctivitis and bulbar congestion, even as isolated signs in the ‘asymptomatic’ patient.

Macrophage Activation in Follicular Conjunctivitis during the COVID-19 Pandemic

Gallenga C. E.
Primo
Writing – Original Draft Preparation
;
Maritati M.
Secondo
;
Mura M.;Di Virgilio F.
Visualization
;
Contini C
Ultimo
Writing – Review & Editing
2023

Abstract

Among the symptoms of SARS-CoV-2, follicular conjunctivitis has become relevant. The conjunctiva acts as an open lymph node, reacting to the viral antigen that binds the epithelial cells, forming follicles of B cells with activated T cells and NK cells on its surface, which, in turn, talk to monocyte-derived inflammatory infected macrophages. Here, the NLRP3 inflammasome is a major driver in releasing pro-inflammatory factors such as IL-6 and caspase-1, leading to follicular conjunctivitis and bulbar congestion, even as isolated signs in the ‘asymptomatic’ patient.
2023
Gallenga, C. E.; Maritati, M.; Mura, M.; Di Virgilio, F.; Conti, P.; Contini, C
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/2521250
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