Perspectives and Pitfalls in Potency Testing of Cannabinoids by High Performance Liquid Chromatography (HPLC)

Cannabis products have been recently legalized in many countries for recreational or medicinal use. Therefore, rigorous analytical methods to test the potency of samples is required prior to commercialization. In addition, growing interest in the properties of minor cannabinoids has increased the demand for high-throughput methods that can separate the largest number of compounds in the shortest amount of time. High performance liquid chromatography (HPLC) is emerging as the preferred analytical method for potency testing of cannabinoids, but more fundamental work is needed to solve critical issues and contribute to advancing knowledge.