Aim: We compared the performances of two different commercial products both based on betamethasone and an antibiotic but using different pharmaceutical vehicles: a polymer and lipid-enriched cream and a conventional oil-in-water emulsion. Methodology: Evaluation was conducted on a reconstructed human epidermis model. Moreover, skin barrier properties and cutaneous hydration of the two vehicles were evaluated on 20 human healthy volunteers. Results: Overall, the polymer and lipid-enriched formulation works as a film-forming product that retains the therapeutic agent for a long time, ensuring its penetration and absorption through the skin, and promoting skin hydration. Conclusion: The above characteristics are useful in the clinical setting, especially in the context of eczematous diseases with a strong xerotic component.
Influences of the vehicle in the spreading and release of betamethasone
Molesini, SoniaPrimo
Investigation
;URTO, FedericaSecondo
Investigation
;Bettoli, VincenzoConceptualization
;Valacchi, GiuseppeMethodology
;Pecorelli, AlessandraInvestigation
;Manfredini, Stefano
Penultimo
Supervision
;Vertuani, SilviaUltimo
Writing – Review & Editing
2018
Abstract
Aim: We compared the performances of two different commercial products both based on betamethasone and an antibiotic but using different pharmaceutical vehicles: a polymer and lipid-enriched cream and a conventional oil-in-water emulsion. Methodology: Evaluation was conducted on a reconstructed human epidermis model. Moreover, skin barrier properties and cutaneous hydration of the two vehicles were evaluated on 20 human healthy volunteers. Results: Overall, the polymer and lipid-enriched formulation works as a film-forming product that retains the therapeutic agent for a long time, ensuring its penetration and absorption through the skin, and promoting skin hydration. Conclusion: The above characteristics are useful in the clinical setting, especially in the context of eczematous diseases with a strong xerotic component.File | Dimensione | Formato | |
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