Review on Medicinal Chemistry, Pharmacology, and Potential Therapeutic Benefits of Cannabinoid CB2 Receptor Agonists

The purpose of this review is to analyze the molecular characterization, distribution, and signal transduction pathways CB2 receptors together with their pharmacological role in some of the most relevant biological systems. The structure and activity relationships of several interesting CB2 agonists, including synthetic schemes to clarify the chemistry involved in this field, are reported in this review. The corresponding pharmacological and beneficial potentials of selected CB2 compounds have been focused upon in the review, along with the patent literature and the identification of promising therapeutic candidates.

Medicinal chemistry, pharmacology, and potential therapeutic benefits of cannabinoid CB2receptor agonists

AGHAZADEH TABRIZI, Mojgan
Primo
;
BARALDI, Pier Giovanni
;
BOREA, Pier Andrea;VARANI, Katia
Ultimo
2016

Abstract

The purpose of this review is to analyze the molecular characterization, distribution, and signal transduction pathways CB2 receptors together with their pharmacological role in some of the most relevant biological systems. The structure and activity relationships of several interesting CB2 agonists, including synthetic schemes to clarify the chemistry involved in this field, are reported in this review. The corresponding pharmacological and beneficial potentials of selected CB2 compounds have been focused upon in the review, along with the patent literature and the identification of promising therapeutic candidates.
2016
AGHAZADEH TABRIZI, Mojgan; Baraldi, Pier Giovanni; Borea, Pier Andrea; Varani, Katia
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Chem. Rev. 2016, 116, 519-560.pdf

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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/2339443
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