In this paper we report the effects of aromatic poly amidines (TAPP-H, TAPB-H and DAPP-H) and their bromo-derivatives (TAPP-Br, TAPB-Br and DAPP-Br) on cell growth and erythroid differentiation of murine Friend erythroleukemic cells. These compounds are strong inhibitors of serine proteinases. The results obtained give evidence (a) for inhibition of cell proliferation by all the aromatic poly-amidines studied; (b) for stronger antiproliferative activity of the Br-derivatives; (c) for a lack of inhibition of globin mRNA accumulation and hemoglobin synthesis is uninduced cells as well as in Friend cells induced to erythroid differentiation by hexamethylenebisacetamide. These results suggest that this class of antiproliferative compounds exhibits differential effects on cell-cycle and differentiation specific genes. Thus, these aromatic poly-amidines could be used in experimental therapy without interfering with differentiative processes also when combined with differentiating agents.
Friend erythroleukemic cells treated with aromatic polyamidines exhibiting antiproteinase activity: inhibition of cell growth is not associated with block of induced erythroid differentiation
Nastruzzi C.;Feriotto G.;Gambari R.
1989
Abstract
In this paper we report the effects of aromatic poly amidines (TAPP-H, TAPB-H and DAPP-H) and their bromo-derivatives (TAPP-Br, TAPB-Br and DAPP-Br) on cell growth and erythroid differentiation of murine Friend erythroleukemic cells. These compounds are strong inhibitors of serine proteinases. The results obtained give evidence (a) for inhibition of cell proliferation by all the aromatic poly-amidines studied; (b) for stronger antiproliferative activity of the Br-derivatives; (c) for a lack of inhibition of globin mRNA accumulation and hemoglobin synthesis is uninduced cells as well as in Friend cells induced to erythroid differentiation by hexamethylenebisacetamide. These results suggest that this class of antiproliferative compounds exhibits differential effects on cell-cycle and differentiation specific genes. Thus, these aromatic poly-amidines could be used in experimental therapy without interfering with differentiative processes also when combined with differentiating agents.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
