Reductive ring cleavage reactions of 3, 5-disubstituted isoxazoles to α,β-unsaturated 1, 4-ketones are reported. The 2, 5-undecanedione (5) was prepared by two different procedures starting from the masked isoxazoles 2 and G. Conversion of 2 and 6 toα, β-unsaturated ketones 3 and 10, followed by selective reduction with an iron-based complex under mild reaction conditions and removal of the protecting ketal group, gave 5. © 1979, American Chemical Society. All rights reserved.
1,4-Diketones via Isoxazole Intermediates
BARCO, AchillePrimo
;BENETTI, SimonettaSecondo
;POLLINI, Gian Piero
;BARALDI, Pier Giovanni;VICENTINI, Chiara BeatriceUltimo
1979
Abstract
Reductive ring cleavage reactions of 3, 5-disubstituted isoxazoles to α,β-unsaturated 1, 4-ketones are reported. The 2, 5-undecanedione (5) was prepared by two different procedures starting from the masked isoxazoles 2 and G. Conversion of 2 and 6 toα, β-unsaturated ketones 3 and 10, followed by selective reduction with an iron-based complex under mild reaction conditions and removal of the protecting ketal group, gave 5. © 1979, American Chemical Society. All rights reserved.File in questo prodotto:
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