We conducted a genome-wide association study for nonsyndromic cleft lip with or without cleft palate (NSCL/P) in 401 1 affected individuals and 1 1,323 controls, with replication in an independent sample of 793 NSCL/P triads. We report two new loci associated with NSCL/P at 1 17q22 (rs227731, combined P = 1 1.07 × 1 10−8, relative risk in homozygotes = 1 1.84, 95% CI 1.34–2.53) and 1 10q25.3 (rs7078160, combined P = 1 1.92 × 1 10−8, relative risk in homozygotes = 2.17, 95% CI 1 1.32–3.56).
Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate
BALUARDO, Carlotta;FERRIAN, Melissa;RUBINI, Michele;
2010
Abstract
We conducted a genome-wide association study for nonsyndromic cleft lip with or without cleft palate (NSCL/P) in 401 1 affected individuals and 1 1,323 controls, with replication in an independent sample of 793 NSCL/P triads. We report two new loci associated with NSCL/P at 1 17q22 (rs227731, combined P = 1 1.07 × 1 10−8, relative risk in homozygotes = 1 1.84, 95% CI 1.34–2.53) and 1 10q25.3 (rs7078160, combined P = 1 1.92 × 1 10−8, relative risk in homozygotes = 2.17, 95% CI 1 1.32–3.56).File in questo prodotto:
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