Modulation of gamma-globin gene expression is of relevance for the treatment of beta-thalassemia and sickle cell anemia. We studied the relationship betwewn the structure of DNA-binding tallimustine analogs and their ability to induce erythroid differentation of K562 cells.
Induction of gamma-globin gene expression by tallimustine analogs in human erythroid cells
CHIARABELLI, CristianoPrimo
;BIANCHI, NicolettaSecondo
;BORGATTI, Monica;GAMBARI, Roberto
Ultimo
2003
Abstract
Modulation of gamma-globin gene expression is of relevance for the treatment of beta-thalassemia and sickle cell anemia. We studied the relationship betwewn the structure of DNA-binding tallimustine analogs and their ability to induce erythroid differentation of K562 cells.File in questo prodotto:
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Chiarabelli C et al Haematologica 2003.pdf
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