PACIFICO, Salvatore
 Distribuzione geografica
Continente #
NA - Nord America 6.604
AS - Asia 3.450
EU - Europa 2.341
SA - Sud America 560
Continente sconosciuto - Info sul continente non disponibili 223
AF - Africa 88
OC - Oceania 8
Totale 13.274
Nazione #
US - Stati Uniti d'America 6.417
SG - Singapore 1.309
IT - Italia 871
CN - Cina 741
VN - Vietnam 431
BR - Brasile 425
PL - Polonia 291
HK - Hong Kong 271
DE - Germania 248
GB - Regno Unito 157
BD - Bangladesh 145
FI - Finlandia 134
TR - Turchia 116
UA - Ucraina 110
FR - Francia 108
JP - Giappone 108
CA - Canada 104
RU - Federazione Russa 82
IN - India 80
SE - Svezia 78
ID - Indonesia 74
IE - Irlanda 55
NL - Olanda 53
MX - Messico 49
AR - Argentina 48
ZA - Sudafrica 38
ES - Italia 32
BE - Belgio 26
PK - Pakistan 24
IQ - Iraq 22
AT - Austria 19
CZ - Repubblica Ceca 19
EC - Ecuador 19
CO - Colombia 18
UZ - Uzbekistan 18
SA - Arabia Saudita 15
VE - Venezuela 13
CL - Cile 12
JO - Giordania 12
PH - Filippine 12
LT - Lituania 11
AE - Emirati Arabi Uniti 10
JM - Giamaica 10
PE - Perù 10
EG - Egitto 8
KR - Corea 8
PY - Paraguay 8
KE - Kenya 7
NP - Nepal 7
TN - Tunisia 7
CH - Svizzera 6
CR - Costa Rica 6
DZ - Algeria 6
IL - Israele 6
KZ - Kazakistan 6
MY - Malesia 6
AL - Albania 5
IR - Iran 5
MA - Marocco 5
UY - Uruguay 5
AU - Australia 4
AZ - Azerbaigian 4
BG - Bulgaria 4
DK - Danimarca 4
HU - Ungheria 4
NG - Nigeria 4
PR - Porto Rico 4
PT - Portogallo 4
AO - Angola 3
DO - Repubblica Dominicana 3
EU - Europa 3
GR - Grecia 3
NO - Norvegia 3
NZ - Nuova Zelanda 3
PA - Panama 3
PS - Palestinian Territory 3
RO - Romania 3
SN - Senegal 3
TH - Thailandia 3
BY - Bielorussia 2
ET - Etiopia 2
GA - Gabon 2
GT - Guatemala 2
KG - Kirghizistan 2
KW - Kuwait 2
LY - Libia 2
MD - Moldavia 2
AM - Armenia 1
BH - Bahrain 1
BJ - Benin 1
BO - Bolivia 1
BS - Bahamas 1
BT - Bhutan 1
CY - Cipro 1
EE - Estonia 1
GD - Grenada 1
GE - Georgia 1
GY - Guiana 1
HN - Honduras 1
HR - Croazia 1
Totale 13.040
Città #
Ashburn 896
Singapore 810
San Jose 648
Fairfield 480
Woodbridge 375
Ferrara 300
Beijing 277
Warsaw 274
Hong Kong 262
Santa Clara 261
Ann Arbor 241
Houston 238
Chandler 212
Seattle 196
Council Bluffs 190
Dallas 184
Cambridge 177
Los Angeles 167
Ho Chi Minh City 165
Wilmington 155
New York 147
Jacksonville 123
Munich 116
Menlo Park 98
Tokyo 95
Hanoi 92
Bologna 80
Milan 74
Jakarta 61
Helsinki 59
Lauterbourg 56
Princeton 55
Shanghai 51
São Paulo 48
Izmir 46
Nanjing 43
Turku 40
Chicago 37
Buffalo 35
Toronto 35
Atlanta 33
Montreal 33
Rome 32
Brooklyn 30
San Diego 29
Orem 27
London 26
Mexico City 26
Brussels 25
Frankfurt am Main 25
Addison 24
Phoenix 24
St Louis 24
Johannesburg 22
The Dalles 22
Chennai 21
Da Nang 21
San Francisco 21
Nanchang 20
Poplar 20
Boardman 19
Boston 19
Dearborn 18
Tashkent 18
Dublin 17
Moscow 17
Amsterdam 15
Belo Horizonte 15
Charlotte 15
Denver 15
Dong Ket 15
Manchester 15
Naples 15
Nuremberg 15
Ankara 14
Lappeenranta 14
Ferrara di Monte Baldo 13
Haiphong 13
Piscataway 13
Redwood City 13
Falkenstein 12
Padova 12
Rio de Janeiro 12
Secaucus 12
Washington 12
Amman 11
Cagliari 11
Guangzhou 11
Lahore 11
Mountain View 11
Stockholm 11
Vienna 11
Brasília 10
Brno 10
Columbus 10
Falls Church 10
Hefei 10
Norwalk 10
Bremen 9
Changsha 9
Totale 8.927
Nome #
Serum beta-secretase 1 (BACE1) activity as candidate biomarker for late-onset Alzheimer’s disease 341
Discovery of Novel 1,3,8-Triazaspiro[4.5]decane Derivatives That Target the c Subunit of F1/FO-Adenosine Triphosphate (ATP) Synthase for the Treatment of Reperfusion Damage in Myocardial Infarction 339
Design, synthesis and evaluation of antiproliferative activity of new benzimidazolehydrazones 305
A diastereoselective synthesis of Cebranopadol, a novel analgesic showing NOP/mu mixed agonism 301
Sintesi di glicopeptidi mediante le reazioni tiol-ene/ino e studio della reattività di Umpolung di α-dichetoni 283
Expeditious Synthesis and Biological Characterization of Enantio-Enriched (-)-Nutlin-3 276
Structure-and conformation-Activity studies of nociceptin/orphanin FQ receptor dimeric ligands 248
Biased Agonism at Nociceptin/Orphanin FQ Receptors: A Structure Activity Study on N/OFQ(1-13)-NH2 247
Structure activity studies of nociceptin/orphanin FQ(1–13)-NH2 derivatives modified in position 5 245
Age differentially impacts adaptive immune responses induced by adenoviral versus mRNA vaccines against COVID-19 240
Discovery of novel fetal hemoglobin inducers for β-thalassemia by small chemical library screening 234
Modulation of the NOP receptor signaling affects resilience to acute stress 232
Peptide welding technology – A simple strategy for generating innovative ligands for G protein coupled receptors 232
Activation of nociceptin/orphanin FQ receptors inhibits contextual fear memory reconsolidation 223
Neuropeptide S receptor ligands: a patent review (2005-2016) 222
One-pot, two-step desymmetrization of symmetrical benzils catalyzed by the methylsulfinyl (dimsyl) anion 220
alpha-Diketones as acyl anion equivalents: a non-enzymatic thiamine-promoted route to aldehyde ketone coupling in PEG(400) as recyclable medium 215
Synthesis and Biological Activity of Peptide α-Ketoamide Derivatives as Proteasome Inhibitors 211
Conveying a newly designed hydrophilic anti-human thymidylate synthase peptide to cisplatin resistant cancer cells: are pH-sensitive liposomes more effective than conventional ones? 209
Indole derivatives as multifunctional drugs: Synthesis and evaluation of antioxidant, photoprotective and antiproliferative activity of indole hydrazones 208
Novel Aryl Sulfonamide Derivatives as NLRP3 Inflammasome Inhibitors for the Potential Treatment of Cancer 204
Increased blood BACE1 activity as a potential common pathogenic factor of vascular dementia and late onset Alzheimer's disease 203
Tetrabranched Hetero-Conjugated Peptides as Bifunctional Agonists of the NOP and Mu Opioid Receptors 200
Impaired Priming of SARS-CoV-2-Specific Naive CD8+ T Cells in Older Subjects 198
Photoinduced addition of glycosyl thiols to alkynyl peptides: use of free-radical thiol-yne coupling for post-translational double-glycosylation of peptides 191
Conformational Propensity and Biological Studies of Proline Mutated LR Peptides Inhibiting Human Thymidylate Synthase and Ovarian Cancer Cell Growth 189
Ageing Curtails the Diversity and Functionality of Nascent CD8+ T Cell Responses against SARS-CoV-2 187
Synthesis of S-glycosyl amino acids and S-glycopeptides via photoinduced click thiol-ene coupling 181
alpha-Diketones as acyl anion equivalents: new enzymatic and non-enzymatic thiamine-promoted routes to aldehyde-ketone coupling 179
Intracellular quantitative detection of human thymidylate synthase engagement with an unconventional inhibitor using tetracysteine-diarsenical-probe technology 176
Bifunctional octadentate pseudopeptides as Zirconium-89 chelators for immuno-PET applications 176
Novel Mixed NOP/Opioid Receptor Peptide Agonists 175
Design and synthesis of 1,4,8-triazaspiro[4.5]decan-2-one derivatives as novel mitochondrial permeability transition pore inhibitors 174
Urotensin-II peptidomimetic incorporating a non-reducible 1,5-triazole disulfide bond reveals a pseudo-irreversible covalent binding mechanism to the urotensin G-protein coupled receptor 169
The Tat Protein of HIV-1 Prevents the Loss of HSV-Specific Memory Adaptive Responses and Favors the Control of Viral Reactivation 166
Structure-Activity Relationship Studies on Oxazolo[3,4- a]pyrazine Derivatives Leading to the Discovery of a Novel Neuropeptide S Receptor Antagonist with Potent in Vivo Activity 166
Synthesis and evaluation of antioxidant and antiproliferative activity of 2-arylbenzimidazoles 165
COMPOSTI PIRROLIDINICI E PIPERIDINICI COME INIBITORI DELL’INFLAMMASOMA NLRP3 E LORO USO COME MEDICAMENTI 162
Serum beta-secretase 1 (BACE1) activity increases in patients with mild cognitive impairment 161
Functional Selectivity Does Not Predict Antinociceptive/Locomotor Impairing Potencies of NOP Receptor Agonists 158
Age, Sex, Hypertension and HDL-C Alter Serum BACE1 Activity in Cognitively Normal Subjects: Implications for Alzheimer's Disease 156
COMPOSTI SOLFONAMMIDICI COME INIBITORI DELL’INFLAMMASOMA NLRP3 E LORO USO COME MEDICAMENTI 154
Compounds as nlrp3 inflammasome inhibitors and their use as medicaments 153
Synthesis of folic acid functionalized gold nanoclusters for targeting folate receptor-positive cells 153
Identification of small-molecule urea derivatives as PTPC modulators targeting the c subunit of F1/Fo-ATP synthase 151
Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth 150
In vitro and in vivo pharmacological characterization of a neuropeptide S tetrabranched derivative 147
Cyclic peptides acting as allosteric inhibitors of human thymidylate synthase and cancer cell growth 146
Effects of non-peptide nociceptin/orphanin FQ receptor ligands on methylphenidate-induced hyperactivity in mice: Implications for bipolar disorders 145
Probing non-peptide agonists binding at the human nociceptin/orphanin FQ receptor: a molecular modelling study 142
Thermodynamic Stability and Speciation of Ga(III) and Zr(IV) Complexes with High-Denticity Hydroxamate Chelators 139
Use of a Novel Peptide Welding Technology Platform for the Development of B- and T-Cell Epitope-Based Vaccines 137
Fluorometric detection of protein-ligand engagement: The case of phosphodiesterase5 136
Thiazolium-catalyzed intermolecular Stetter reaction of linear and cyclic alkyl α-diketones 134
A Peptidic Thymidylate-Synthase Inhibitor Loaded on Pegylated Liposomes Enhances the Antitumour Effect of Chemotherapy Drugs in Human Ovarian Cancer Cells 132
Sex differences in response to NLRP3 inflammasome blockage in a mouse migraine model: A genetic and pharmacological study 126
Thiazolium-functionalized polystyrene monolithic microreactors for continuous-flow umpolung catalysis 125
COMPOSTI TETRAIDROISOCHINOLINICI COME INIBITORI DELL’INFLAMMASOMA NLRP3 E LORO USO COME MEDICAMENTI 121
Identification of isoxazole-based TRPA1 inhibitors with analgesic effects in vivo 121
In vitro pharmacological evaluation of the novel NOP receptor partial agonist sunobinop 121
FAP inhibitors: are we really using the best method to evaluate the residence time? 116
Folic Acid-Peptide Conjugates Combine Selective Cancer Cell Internalization with Thymidylate Synthase Dimer Interface Targeting 116
Reactivity of dialkyl and diaryl alpha-diketones with N-heterocyclic carbenes 113
null 110
Dimethyl Sulfoxide and N,N-dimethylformamide as Umpolung Pre-catalysts in Cross Benzoin Reactions of alpha-Diketones with Aldehydes 108
null 108
Probing the Effect of Sildenafil on Progesterone and Testosterone Production by an Intracellular FRET/BRET Combined Approach 107
Phosphodiesterase (PDE) 5 inhibitors sildenafil, tadalafil and vardenafil impact cAMP-specific PDE8 isoforms-linked second messengers and steroid production in a mouse Leydig tumor cell line 106
Thiazolium-Functionalized Polystyrene Monolithic Microreactors for Continuous-Flow Umpolung Catalysis 95
null 94
Methylsulfinyl (Dimsyl) Anion as Umpolung Catalyst for the Chemoselective Cross Benzoin Reaction of α-Diketones with Aldehydes 92
null 92
Synthesis and Pharmacological Characterization of Nociceptin/Orphanin FQ Dimeric Ligands 88
Identification of pyrazolo-piperidinone derivatives targeting YAP-TEAD interface 3 as anticancer agents through integrated virtual screening and mass spectrometry proteomics 87
Thermodynamic and spectroscopic analysis of peptide-based enzyme mimics containing the ATCUN site 84
null 79
Unexpected reactivity of diaryl α-diketones with thiazolium carbenes: discovery of a novel multicomponent reaction for the facile synthesis of 1,4-thiazin-3-ones 73
Synthesis of Chiral Ionic Liquids from Natural Monosaccharides 69
Thermodynamic and spectroscopic analysis of peptide-based enzyme mimics containing the ATCUN site 60
null 57
Comprehensive transduceromic profiling of NOP receptor ligands at different Gα subunits 20
Totale 13.274
Categoria #
all - tutte 59.379
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 59.379


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022659 0 91 147 32 27 33 43 26 33 51 34 142
2022/2023522 57 61 12 60 73 53 49 45 55 3 39 15
2023/2024481 50 47 24 25 25 81 25 47 22 24 14 97
2024/20251.904 67 38 160 96 162 154 51 95 342 189 289 261
2025/20266.215 567 311 541 666 887 390 744 361 555 692 319 182
2026/2027503 272 231 0 0 0 0 0 0 0 0 0 0
Totale 13.274