PACIFICO, Salvatore
 Distribuzione geografica
Continente #
NA - Nord America 4.819
AS - Asia 2.308
EU - Europa 1.801
SA - Sud America 431
AF - Africa 47
OC - Oceania 4
Continente sconosciuto - Info sul continente non disponibili 3
Totale 9.413
Nazione #
US - Stati Uniti d'America 4.710
SG - Singapore 1.022
IT - Italia 612
CN - Cina 576
BR - Brasile 356
PL - Polonia 282
HK - Hong Kong 236
DE - Germania 231
VN - Vietnam 152
GB - Regno Unito 126
UA - Ucraina 104
TR - Turchia 103
FI - Finlandia 81
RU - Federazione Russa 77
ID - Indonesia 67
CA - Canada 59
SE - Svezia 53
IE - Irlanda 50
MX - Messico 41
FR - Francia 36
IN - India 32
NL - Olanda 32
AR - Argentina 31
ZA - Sudafrica 27
JP - Giappone 26
BE - Belgio 24
ES - Italia 23
BD - Bangladesh 21
CZ - Repubblica Ceca 19
AT - Austria 16
EC - Ecuador 12
LT - Lituania 10
PE - Perù 8
PK - Pakistan 8
UZ - Uzbekistan 8
CL - Cile 7
IQ - Iraq 7
AE - Emirati Arabi Uniti 6
CO - Colombia 6
KR - Corea 6
KZ - Kazakistan 6
SA - Arabia Saudita 6
JO - Giordania 5
NP - Nepal 5
VE - Venezuela 5
AL - Albania 4
BG - Bulgaria 4
EG - Egitto 4
IL - Israele 4
IR - Iran 4
PY - Paraguay 4
CH - Svizzera 3
CR - Costa Rica 3
DZ - Algeria 3
EU - Europa 3
KE - Kenya 3
MA - Marocco 3
AO - Angola 2
AU - Australia 2
DK - Danimarca 2
KW - Kuwait 2
PT - Portogallo 2
RO - Romania 2
SN - Senegal 2
TN - Tunisia 2
AM - Armenia 1
AZ - Azerbaigian 1
BO - Bolivia 1
BS - Bahamas 1
BY - Bielorussia 1
DO - Repubblica Dominicana 1
GA - Gabon 1
GD - Grenada 1
GR - Grecia 1
GT - Guatemala 1
HU - Ungheria 1
KG - Kirghizistan 1
LU - Lussemburgo 1
LV - Lettonia 1
MK - Macedonia 1
MY - Malesia 1
NO - Norvegia 1
NZ - Nuova Zelanda 1
OM - Oman 1
PA - Panama 1
PR - Porto Rico 1
SK - Slovacchia (Repubblica Slovacca) 1
TV - Tuvalu 1
TW - Taiwan 1
UY - Uruguay 1
Totale 9.413
Città #
Ashburn 600
Singapore 561
Fairfield 480
Woodbridge 374
Ferrara 271
Warsaw 269
Beijing 251
Ann Arbor 241
Hong Kong 234
Houston 227
Santa Clara 224
Chandler 212
Seattle 195
Cambridge 177
Dallas 175
Wilmington 154
Los Angeles 127
Jacksonville 120
Munich 116
New York 106
Menlo Park 98
Ho Chi Minh City 63
Jakarta 61
Bologna 60
Princeton 55
Milan 48
Shanghai 48
Izmir 45
Nanjing 41
Turku 40
São Paulo 39
Chicago 30
Brooklyn 28
San Diego 28
Montreal 27
Hanoi 26
Addison 24
Atlanta 24
Brussels 24
Mexico City 24
Tokyo 23
St Louis 22
Buffalo 20
London 20
Nanchang 20
Boardman 19
Poplar 19
Dearborn 18
Helsinki 18
The Dalles 18
Johannesburg 17
Moscow 17
Rome 17
San Francisco 17
Boston 16
Frankfurt am Main 16
Dong Ket 15
Chennai 14
Nuremberg 14
Belo Horizonte 13
Denver 13
Ferrara di Monte Baldo 13
Orem 13
Phoenix 13
Redwood City 13
Dublin 12
Falkenstein 12
Padova 12
Ankara 11
Charlotte 11
Mountain View 11
Brno 10
Columbus 10
Falls Church 10
Hefei 10
Norwalk 10
Rio de Janeiro 10
Toronto 10
Brasília 9
Bremen 9
Stockholm 9
Tianjin 9
Cagliari 8
Des Moines 8
Manchester 8
Tashkent 8
Vienna 8
Guangzhou 7
Jinan 7
Olomouc 7
Pittsburgh 7
San Mateo 7
Shenyang 7
Washington 7
Amsterdam 6
Bexley 6
Buenos Aires 6
Calgary 6
Caxias do Sul 6
Changsha 6
Totale 6.665
Nome #
Serum beta-secretase 1 (BACE1) activity as candidate biomarker for late-onset Alzheimer’s disease 298
A diastereoselective synthesis of Cebranopadol, a novel analgesic showing NOP/mu mixed agonism 255
Design, synthesis and evaluation of antiproliferative activity of new benzimidazolehydrazones 247
Discovery of Novel 1,3,8-Triazaspiro[4.5]decane Derivatives That Target the c Subunit of F1/FO-Adenosine Triphosphate (ATP) Synthase for the Treatment of Reperfusion Damage in Myocardial Infarction 247
Sintesi di glicopeptidi mediante le reazioni tiol-ene/ino e studio della reattività di Umpolung di α-dichetoni 244
Expeditious Synthesis and Biological Characterization of Enantio-Enriched (-)-Nutlin-3 229
Structure activity studies of nociceptin/orphanin FQ(1–13)-NH2 derivatives modified in position 5 202
Biased Agonism at Nociceptin/Orphanin FQ Receptors: A Structure Activity Study on N/OFQ(1-13)-NH2 195
Modulation of the NOP receptor signaling affects resilience to acute stress 193
Structure-and conformation-Activity studies of nociceptin/orphanin FQ receptor dimeric ligands 193
One-pot, two-step desymmetrization of symmetrical benzils catalyzed by the methylsulfinyl (dimsyl) anion 180
Discovery of novel fetal hemoglobin inducers for β-thalassemia by small chemical library screening 175
Peptide welding technology – A simple strategy for generating innovative ligands for G protein coupled receptors 173
Conveying a newly designed hydrophilic anti-human thymidylate synthase peptide to cisplatin resistant cancer cells: are pH-sensitive liposomes more effective than conventional ones? 169
Photoinduced addition of glycosyl thiols to alkynyl peptides: use of free-radical thiol-yne coupling for post-translational double-glycosylation of peptides 169
Neuropeptide S receptor ligands: a patent review (2005-2016) 169
Increased blood BACE1 activity as a potential common pathogenic factor of vascular dementia and late onset Alzheimer's disease 169
Activation of nociceptin/orphanin FQ receptors inhibits contextual fear memory reconsolidation 168
alpha-Diketones as acyl anion equivalents: a non-enzymatic thiamine-promoted route to aldehyde ketone coupling in PEG(400) as recyclable medium 165
Indole derivatives as multifunctional drugs: Synthesis and evaluation of antioxidant, photoprotective and antiproliferative activity of indole hydrazones 163
Synthesis and Biological Activity of Peptide α-Ketoamide Derivatives as Proteasome Inhibitors 162
Tetrabranched Hetero-Conjugated Peptides as Bifunctional Agonists of the NOP and Mu Opioid Receptors 153
Synthesis of S-glycosyl amino acids and S-glycopeptides via photoinduced click thiol-ene coupling 152
Novel Aryl Sulfonamide Derivatives as NLRP3 Inflammasome Inhibitors for the Potential Treatment of Cancer 146
Conformational Propensity and Biological Studies of Proline Mutated LR Peptides Inhibiting Human Thymidylate Synthase and Ovarian Cancer Cell Growth 144
Urotensin-II peptidomimetic incorporating a non-reducible 1,5-triazole disulfide bond reveals a pseudo-irreversible covalent binding mechanism to the urotensin G-protein coupled receptor 143
Intracellular quantitative detection of human thymidylate synthase engagement with an unconventional inhibitor using tetracysteine-diarsenical-probe technology 141
Synthesis and evaluation of antioxidant and antiproliferative activity of 2-arylbenzimidazoles 139
alpha-Diketones as acyl anion equivalents: new enzymatic and non-enzymatic thiamine-promoted routes to aldehyde-ketone coupling 136
The Tat Protein of HIV-1 Prevents the Loss of HSV-Specific Memory Adaptive Responses and Favors the Control of Viral Reactivation 132
Age differentially impacts adaptive immune responses induced by adenoviral versus mRNA vaccines against COVID-19 130
Ageing Curtails the Diversity and Functionality of Nascent CD8+ T Cell Responses against SARS-CoV-2 129
Impaired Priming of SARS-CoV-2-Specific Naive CD8+ T Cells in Older Subjects 128
Structure-Activity Relationship Studies on Oxazolo[3,4- a]pyrazine Derivatives Leading to the Discovery of a Novel Neuropeptide S Receptor Antagonist with Potent in Vivo Activity 123
Novel Mixed NOP/Opioid Receptor Peptide Agonists 115
Synthesis of folic acid functionalized gold nanoclusters for targeting folate receptor-positive cells 113
Fluorometric detection of protein-ligand engagement: The case of phosphodiesterase5 112
null 110
Bifunctional octadentate pseudopeptides as Zirconium-89 chelators for immuno-PET applications 110
Design and synthesis of 1,4,8-triazaspiro[4.5]decan-2-one derivatives as novel mitochondrial permeability transition pore inhibitors 109
null 108
Effects of non-peptide nociceptin/orphanin FQ receptor ligands on methylphenidate-induced hyperactivity in mice: Implications for bipolar disorders 107
Age, Sex, Hypertension and HDL-C Alter Serum BACE1 Activity in Cognitively Normal Subjects: Implications for Alzheimer's Disease 105
Thiazolium-catalyzed intermolecular Stetter reaction of linear and cyclic alkyl α-diketones 105
In vitro and in vivo pharmacological characterization of a neuropeptide S tetrabranched derivative 104
Identification of small-molecule urea derivatives as PTPC modulators targeting the c subunit of F1/Fo-ATP synthase 103
Functional Selectivity Does Not Predict Antinociceptive/Locomotor Impairing Potencies of NOP Receptor Agonists 102
Use of a Novel Peptide Welding Technology Platform for the Development of B- and T-Cell Epitope-Based Vaccines 100
Serum beta-secretase 1 (BACE1) activity increases in patients with mild cognitive impairment 100
Probing non-peptide agonists binding at the human nociceptin/orphanin FQ receptor: a molecular modelling study 98
Cyclic peptides acting as allosteric inhibitors of human thymidylate synthase and cancer cell growth 98
null 94
A Peptidic Thymidylate-Synthase Inhibitor Loaded on Pegylated Liposomes Enhances the Antitumour Effect of Chemotherapy Drugs in Human Ovarian Cancer Cells 92
null 92
Thermodynamic Stability and Speciation of Ga(III) and Zr(IV) Complexes with High-Denticity Hydroxamate Chelators 91
COMPOSTI SOLFONAMMIDICI COME INIBITORI DELL’INFLAMMASOMA NLRP3 E LORO USO COME MEDICAMENTI 90
Reactivity of dialkyl and diaryl alpha-diketones with N-heterocyclic carbenes 86
Folic Acid-Peptide Conjugates Combine Selective Cancer Cell Internalization with Thymidylate Synthase Dimer Interface Targeting 86
Thiazolium-functionalized polystyrene monolithic microreactors for continuous-flow umpolung catalysis 85
COMPOSTI PIRROLIDINICI E PIPERIDINICI COME INIBITORI DELL’INFLAMMASOMA NLRP3 E LORO USO COME MEDICAMENTI 80
null 79
Dimethyl Sulfoxide and N,N-dimethylformamide as Umpolung Pre-catalysts in Cross Benzoin Reactions of alpha-Diketones with Aldehydes 78
Probing the Effect of Sildenafil on Progesterone and Testosterone Production by an Intracellular FRET/BRET Combined Approach 78
Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth 78
COMPOSTI TETRAIDROISOCHINOLINICI COME INIBITORI DELL’INFLAMMASOMA NLRP3 E LORO USO COME MEDICAMENTI 73
Compounds as nlrp3 inflammasome inhibitors and their use as medicaments 72
Thiazolium-Functionalized Polystyrene Monolithic Microreactors for Continuous-Flow Umpolung Catalysis 71
null 57
FAP inhibitors: are we really using the best method to evaluate the residence time? 53
Identification of isoxazole-based TRPA1 inhibitors with analgesic effects in vivo 52
Methylsulfinyl (Dimsyl) Anion as Umpolung Catalyst for the Chemoselective Cross Benzoin Reaction of α-Diketones with Aldehydes 51
In vitro pharmacological evaluation of the novel NOP receptor partial agonist sunobinop 51
Phosphodiesterase (PDE) 5 inhibitors sildenafil, tadalafil and vardenafil impact cAMP-specific PDE8 isoforms-linked second messengers and steroid production in a mouse Leydig tumor cell line 51
Unexpected reactivity of diaryl α-diketones with thiazolium carbenes: discovery of a novel multicomponent reaction for the facile synthesis of 1,4-thiazin-3-ones 50
Synthesis of Chiral Ionic Liquids from Natural Monosaccharides 48
Thermodynamic and spectroscopic analysis of peptide-based enzyme mimics containing the ATCUN site 37
Sex differences in response to NLRP3 inflammasome blockage in a mouse migraine model: A genetic and pharmacological study 33
Identification of pyrazolo-piperidinone derivatives targeting YAP-TEAD interface 3 as anticancer agents through integrated virtual screening and mass spectrometry proteomics 33
Synthesis and Pharmacological Characterization of Nociceptin/Orphanin FQ Dimeric Ligands 14
Thermodynamic and spectroscopic analysis of peptide-based enzyme mimics containing the ATCUN site 9
Totale 9.624
Categoria #
all - tutte 47.870
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 47.870


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021682 0 0 0 0 0 93 92 115 46 178 76 82
2021/2022690 31 91 147 32 27 33 43 26 33 51 34 142
2022/2023522 57 61 12 60 73 53 49 45 55 3 39 15
2023/2024481 50 47 24 25 25 81 25 47 22 24 14 97
2024/20251.904 67 38 160 96 162 154 51 95 342 189 289 261
2025/20263.068 567 311 541 666 887 96 0 0 0 0 0 0
Totale 9.624