SECCHIERO, Paola
 Distribuzione geografica
Continente #
NA - Nord America 27.810
AS - Asia 13.436
EU - Europa 7.666
SA - Sud America 2.194
AF - Africa 315
OC - Oceania 28
Continente sconosciuto - Info sul continente non disponibili 5
AN - Antartide 1
Totale 51.455
Nazione #
US - Stati Uniti d'America 27.293
SG - Singapore 5.081
CN - Cina 3.274
IT - Italia 1.976
BR - Brasile 1.741
VN - Vietnam 1.486
DE - Germania 1.127
HK - Hong Kong 1.084
UA - Ucraina 1.067
GB - Regno Unito 772
TR - Turchia 740
PL - Polonia 676
FI - Finlandia 473
FR - Francia 412
BD - Bangladesh 393
RU - Federazione Russa 346
JP - Giappone 295
SE - Svezia 284
IN - India 261
CA - Canada 254
ID - Indonesia 228
MX - Messico 181
AR - Argentina 179
ZA - Sudafrica 129
NL - Olanda 114
IQ - Iraq 99
ES - Italia 91
PK - Pakistan 73
EC - Ecuador 64
BE - Belgio 57
VE - Venezuela 55
CO - Colombia 53
UZ - Uzbekistan 52
SA - Arabia Saudita 51
LT - Lituania 41
CZ - Repubblica Ceca 39
MY - Malesia 39
MA - Marocco 37
CL - Cile 33
AT - Austria 32
EG - Egitto 32
PH - Filippine 27
TN - Tunisia 26
AE - Emirati Arabi Uniti 24
AU - Australia 24
PY - Paraguay 24
DZ - Algeria 22
JO - Giordania 20
KE - Kenya 20
KR - Corea 20
IR - Iran 19
TW - Taiwan 19
CH - Svizzera 17
JM - Giamaica 17
UY - Uruguay 17
AZ - Azerbaigian 16
BO - Bolivia 16
EE - Estonia 15
IL - Israele 15
RO - Romania 15
CR - Costa Rica 14
IE - Irlanda 14
KG - Kirghizistan 14
NP - Nepal 14
OM - Oman 14
LK - Sri Lanka 13
PT - Portogallo 12
TH - Thailandia 11
BG - Bulgaria 10
DO - Repubblica Dominicana 10
GR - Grecia 10
HN - Honduras 10
PS - Palestinian Territory 10
RS - Serbia 10
ET - Etiopia 9
PE - Perù 9
KZ - Kazakistan 8
SN - Senegal 8
AL - Albania 7
CI - Costa d'Avorio 7
LB - Libano 7
DK - Danimarca 6
GE - Georgia 6
MD - Moldavia 6
NI - Nicaragua 6
SK - Slovacchia (Repubblica Slovacca) 6
TT - Trinidad e Tobago 6
HR - Croazia 5
CY - Cipro 4
GT - Guatemala 4
LV - Lettonia 4
LY - Libia 4
PA - Panama 4
TG - Togo 4
BN - Brunei Darussalam 3
HU - Ungheria 3
KW - Kuwait 3
MK - Macedonia 3
SI - Slovenia 3
SR - Suriname 3
Totale 51.391
Città #
Ashburn 3.349
Singapore 3.116
Fairfield 2.805
Woodbridge 2.507
San Jose 1.667
Houston 1.652
Jacksonville 1.169
Seattle 1.141
Chandler 1.099
Hong Kong 1.065
Ann Arbor 1.062
Santa Clara 1.019
Wilmington 992
Beijing 978
Cambridge 956
Warsaw 660
Ferrara 621
Dallas 544
Los Angeles 490
Ho Chi Minh City 483
New York 413
Izmir 371
Hanoi 342
Nanjing 339
Council Bluffs 309
Princeton 280
Tokyo 277
Lauterbourg 254
Munich 236
Boardman 233
Milan 221
San Diego 214
São Paulo 179
Helsinki 166
Jakarta 166
Shanghai 152
Orem 129
Buffalo 128
London 114
Mexico City 109
Bologna 108
Nanchang 108
Shenyang 105
Chicago 104
Dearborn 98
Tianjin 91
Denver 90
Montreal 86
Brooklyn 82
Chennai 79
The Dalles 78
Hefei 76
Turku 73
Da Nang 72
Frankfurt am Main 72
Falls Church 70
Johannesburg 70
Atlanta 67
Changsha 65
San Francisco 64
Hebei 59
Rome 58
Toronto 58
Moscow 57
Dong Ket 56
Poplar 56
Brussels 55
Jiaxing 55
Mountain View 54
Haiphong 53
Columbus 52
Stockholm 52
Phoenix 48
Bremen 47
Manchester 46
Boston 45
Zhengzhou 43
Tashkent 42
Rio de Janeiro 41
San Mateo 41
Baghdad 39
Kunming 39
Norwalk 39
Jinan 38
Redwood City 37
Auburn Hills 35
Guangzhou 34
Mumbai 34
Verona 34
Hải Dương 33
Tappahannock 32
Ankara 30
Matera 30
Istanbul 29
Nuremberg 29
Brasília 28
Porto Alegre 28
Washington 28
Brno 27
Falkenstein 27
Totale 35.333
Nome #
Gene-gene interactions among coding genes of iron-homeostasis proteins and APOE-alleles in Cognitive Impairment Diseases 487
Cell cycle block by p53 acrivation reduces SARS-COV-2 release in infected alveolar basal epithelial A549-hACE2 cells 345
Design, synthesis and biological characterization of novel mitochondria targeted dichloroacetate-loaded compounds with antileukemic activity 333
Anti-leukemic activity of microRNA-26a in a chronic lymphocytic leukemia mouse model 301
Cell cycle block by p53 activation reduces SARS-CoV-2 release in infected alveolar basal epithelial A549-hACE2 cells 278
Serum From Advanced Heart Failure Patients Promotes Angiogenic Sprouting and Affects the Notch Pathway in Human Endothelial Cells 277
The anti-leukemic activity of sodium dichloroacetate in p53(mutated/null) cells is mediated by a p53-independent ILF3/p21 pathway 275
Intranasal Administration of Recombinant TRAIL Down-Regulates CXCL-1/KC in an Ovalbumin-Induced Airway Inflammation Murine Model 275
Sodium dichloroacetate exhibits anti-leukemic activity in B-chronic lymphocytic leukemia (B-CLL) and synergizes with the p53 activator Nutlin-3 272
Expeditious Synthesis and Biological Characterization of Enantio-Enriched (-)-Nutlin-3 271
Anticancer Activity of Aqueous Extracts from Asparagus officinalis L. Byproduct on Breast Cancer Cells 269
MDM2/X inhibitors under clinical evaluation: Perspectives for the management of hematological malignancies and pediatric cancer 268
Ibrutinib synergizes with MDM-2 inhibitors in promoting cytotoxicity in B chronic lymphocytic leukemia 265
Nutlin-3 up-regulates the expression of Notch1 in both myeloid and lymphoid leukemic cells, as part of a negative feedback antiapoptotic mechanism 261
COVID-19 and individual genetic susceptibility/receptivity: Role of ACE1/ACE2 genes, immunity, inflammation and coagulation. might the double x-chromosome in females be protective against SARS-COV-2 compared to the single x-chromosome in males? 258
A set of NF-κB-regulated microRNAs induces acquired TRAIL resistance in Lung cancer 256
Synergistic cytotoxic activity of recombinant TRAIL plus the non-genotoxic activator of the p53 pathway nutlin-3 in acute myeloid leukemia cells 250
Antiangiogenic activity of the MDM2 antagonist nutlin-3 250
Conjunctival sac fluid contains elevated levels of soluble TRAIL: implications for the anti-tumoral surveillance of the anterior surface of the eye 250
Actively targeted nanocarriers for drug delivery to cancer cells 250
Association between thyroid hormones and TRAIL 249
HelixComplex snail mucus exhibits pro-survival, proliferative and pro-migration effects on mammalian fibroblasts 246
CCR4+ skin-tropic phenotype as a feature of central memory CD8+ T cells in healthy subjects and psoriasis patients 245
Association of serum tumor necrosis factor-related apoptosis inducing ligand with body fat distribution as assessed by dual X-rays absorptiometry 242
Characterization of human herpesvirus 6 strains isolated from patients with exanthem subitum with or without cutaneous rash 241
Association of tumor necrosis factor-related apoptosis-inducing ligand with total and cardiovascular mortality in older adults 241
Coagulation Factor XII Levels and Intrinsic Thrombin Generation in Multiple Sclerosis 238
Serum Soluble Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Levels in Older Subjects with Dementia and Mild Cognitive Impairment 236
Multiple dye-doped NIR-emitting silica nanoparticles for both flow cytometry and in vivo imaging 233
Elevated levels of TRAIL in systemic lupus erythematosus are associated to the presence of anti-SSA/SSB antibodies 229
GM-CSF Exhibits Anti-Inflammatory Activity on Endothelial Cells Derived from Chronic Venous Disease Patients 229
Metformin combined with sodium dichloroacetate promotes B leukemic cell death by suppressing anti-apoptotic protein Mcl-1 229
Differential gene expression induction by TRAIL in B chronic lymphocytic leukemia (B-CLL) cells showing high versus low levels of Zap-70 228
TRAIL and Ceruloplasmin Inverse Correlation as a Representative Crosstalk between Inflammation and Oxidative Stress 228
Upregulation of the alternative splicing factor NOVA2 in colorectal cancer vasculature 228
TNF-related apoptosis inducing ligand in ocular cancers and ocular diabetic complications 227
Characterization Methods for Nanoparticle–Skin Interactions: An Overview 226
The circulating levels of TRAIL are extremely low after delivery but rapidly recover in both mothers and newborns 226
The MDM-2 antagonist nutlin-3 promotes the maturation of acute myeloid leukemic blasts 225
Circulating levels of frizzled-related protein (FRZB) are increased in patients with early rheumatoid arthritis and decrease in response to disease-modifying antirheumatic drugs. 225
Human bone marrow mesenchymal stem cells display anti-cancer activity in SCID mice bearing disseminated non-hodgkin's lymphoma xenografts 225
Evidence for a role of TNF-related apoptosis-inducing ligand (TRAIL) in the anemia of myelodysplastic syndromes 224
Association of Soluble Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) with Central Adiposity and Low-Density Lipoprotein Cholesterol 224
The p53 transcriptional pathway is preserved in ATMmutated and NOTCH1mutated chronic lymphocytic leukemias 224
Anti-leukemic activity of Dasatinib in both p53 wild-type and p53 mutated B malignant cells 223
Clinical perspectives of TRAIL: Insights into central nervous system disorders 222
TRAIL promotes the survival, migration and proliferation of vascular smooth muscle cells 221
Context-dependent function of ROS in the vascular endothelium: The role of the Notch pathway and shear stress 219
The 85-kilodalton phosphoprotein (pp85) of human herpesvirus 7 is encoded by open reading frame U14 and localizes to a tegument substructure in virion particles 215
Kinetic Profiles of Inflammatory Mediators in the Conjunctival Sac Fluid of Patients upon Photorefractive Keratectomy 215
In Vitro Characterization of Circulating Endothelial Progenitor Cells Isolated from Patients with Acute Coronary Syndrome 214
Cyclooxygenase-2 expression is induced during human megakaryopoiesis and characterizes newly formed platelets 214
TRAIL counteracts the proadhesive activity of inflammatory cytokines in endothelial cells by down-modulating CCL8 and CXCL10 chemokine expression and release 213
Human Herpesvirus 7 infection induces profound cell cycle perturbations coupled to disregulation of cdc2 and cyclin B and polyploidization of CD4+ T Cells 212
Nanoparticles Loaded with Nutlin-3 Display Cytotoxicity Towards p53(wild-type) JVM-2 But Not Towards p53(mutated) BJAB Leukemic Cells 212
Functional integrity of the p53-mediated apoptotic pathway induced by the nongenotoxic agent nutlin-3 in B-cell chronic lymphocytic leukemia (B-CLL) 212
Applications of nanoparticles in cancer medicine and beyond: optical and multimodal in vivo imaging, tissue targeting and drug delivery 212
The effectiveness of Robot-Assisted Gait Training versus conventional therapy on mobility in severely disabled progressIve MultiplE sclerosis patients (RAGTIME): Study protocol for a randomized controlled trial 210
Redox signaling and oxidative stress: Cross talk with TNF-related apoptosis inducing ligand activity 210
HIV-1 Tat-mediated inhibition of the tyrosine hydroxylase gene expression in dopaminergic neuronal cells 208
Activated human NK and CD8+ T cells express both TNF-related apoptosis-inducing ligand (TRAIL) and TRAIL receptors but are resistant to TRAIL-mediated cytotoxicity 208
Hydrogen sulfide down-regulates the expression and release of osteoprotegerin (OPG) by vascular endothelial cells 208
In vivo anti-lymphoma activity of an agonistic human recombinant anti-TRAIL-R2 minibody. 208
Is there any role for tumour necrosis factor related apoptosis inducing ligand–osteoprotegerin (TRAIL–OPG) interaction in rheumatoid arthritis? 207
Circulating TRAIL shows a significant post-partum decline associated to stressful conditions 207
MDM2 antagonist Nutlin-3 suppresses the proliferation and differentiation of human pre-osteoclasts through a p53-dependent pathway 205
Effects of hypoxia and bed rest on markers of cardiometabolic risk: Compensatory changes in circulating trail and glutathione redox capacity 205
Eosinophils and purinergic signaling in health and disease 205
The Sorafenib plus Nutlin-3 combination promotes synergistic cytotoxicity in acute myeloid leukemic cells irrespectively of the FLT3 and p53 status 204
Involvement of TRAIL/TRAIL-receptors in human intestinal cell differentiation 203
MicroRNA-148a reduces tumorigenesis and increases TRAIL-induced apoptosis in NSCLC 203
HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway 202
Combined treatment of CpG-oligodeoxynucleotide with Nutlin-3 induces strong immune stimulation coupled to cytotoxicity in B-chronic lymphocytic leukemic (B-CLL) cells 202
The MDM2 inhibitor Nutlin-3 attenuates streptozotocin-induced diabetes mellitus and increases serum level of IL-12p40. 201
Relationship between low levels of circulating TRAIL and atheromatosis progression in patients with chronic kidney disease 198
Anti-Inflammatory and Cortical Responses after Transcranial Direct Current Stimulation in Disorders of Consciousness: An Exploratory Study 197
A novel endovenous scaffold for the treatment of chronic venous obstruction in a porcine model: Histological and ultrastructural assessment 197
Plasma levels of soluble NCAM in multiple sclerosis 197
SARS-CoV-2 nucleocapsid-protein and ultrastructural modifications in small bowel of a four week negative COVID-19 patient 197
Proper design of silica nanoparticles combines high brightness, lack of cytotoxicity and efficient cell endocytosis 195
Multimodal near-infrared-emitting PluS Silica nanoparticles with fluorescent, photoacoustic, and photothermal capabilities 195
Molecular targets for selective killing of TRAIL-resistant leukemic cells. 194
Mesenchymal stem cells display hepato-protective activity in lymphoma bearing xenografts 194
Metabolic Syndrome and Psoriasis: Pivotal Roles of Chronic Inflammation and Gut Microbiota 193
Release of a specific set of proinflammatory adipokines by differentiating 3T3-L1 cells 191
Engagement of CD28 modulates CXC chemokine receptor 4 surface expression in both resting and CD3-stimulated CD4+ T cells 191
Association of human herpes virus 6 (HHV-6) with multiple sclerosis: Increased IgM response to HHV-6 early antigen and detection of serum HHV-6 DNA 191
Chemoresistive Nanostructured Sensors for Tumor Pre-Screening 189
Tumor necrosis factor-related apoptosis-inducing ligand promotes migration of human bone marrow multipotent stromal cells 188
Endothelial PDGF-BB produced ex vivo correlates with relevant hemodynamic parameters in patients affected by chronic venous disease 188
Osteoprotegerin induces morphological and functional alterations in mouse pancreatic islets. 187
MDM4 (MDMX) is overexpressed in chronic lymphocytic leukaemia (CLL) and marks a subset of p53wild-type CLL with a poor cytotoxic response to Nutlin-3. 187
Activation of the p53 pathway down-regulates the osteoprotegerin expression and release by vascular endothelial cells 187
In-vitro anticancer activity of Asparagus officinalis extracts on breast carcinoma 186
TRAIL inhibits osteoclastic differentiation by counteracting RANKL-dependent p27Kip1 accumulation in pre-osteoclast precursors 182
Circulating levels of TNF-related apoptosis inducing-ligand are decreased in patients with large adult-type granulosa cell tumors—implications for therapeutic potential 182
Activation of the nitric oxide synthase pathway represents a key component of the TNF-related apoptosis-inducing ligand (TRAIL)-mediated cytotoxicity on hematological malignancies. 182
Pivotal role of cyclic nucleoside phosphodiesterase 4 in Tat-mediated CD4+ T cell hyperactivation and HIV type 1 replication 181
State of art and recent developments of anti-cancer strategies based on TRAIL 181
Functional recovery in multiple sclerosis patients undergoing rehabilitation programs is associated with plasma levels of hemostasis inhibitors 179
Totale 22.488
Categoria #
all - tutte 222.545
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 222.545


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021276 0 0 0 0 0 0 0 0 0 0 0 276
2021/20222.870 87 314 220 115 161 164 175 165 101 233 334 801
2022/20232.687 296 131 95 311 408 394 116 245 358 48 160 125
2023/20241.451 162 182 53 38 105 201 45 148 30 30 59 398
2024/20256.733 214 192 533 310 851 515 285 389 1.154 632 957 701
2025/202619.964 1.835 862 1.785 2.370 2.681 1.349 2.226 1.093 1.917 2.255 1.130 461
Totale 52.032