Introduction: the available studies on extraction wound repair in humans are affected by significant limitations and failed to evaluate tissue alterations occurring in all compartments of the hard tissue defect. Aim: monitor during a 6 month period the healing of human extraction sockets and include a semi-quantitative analysis of tissues and cell populations involved in various stages of the processes of modeling/remodeling. Materials & Methods: 27 biopsies, representative of the early (2-4 weeks; n= 10), intermediate (6-8 weeks; n= 6), and late phase (12-24 weeks; n= 11) of healing, were collected and analyzed. Results: granulation tissue that was present in comparatively large amounts in the early healing phase of socket healing, was in the interval between the early and intermediate observation phase replaced with provisional matrix and woven bone. The density of vascular structures and macrophages slowly decreased from 2-4 weeks over time. The presence of osteoblasts peaked at 6-8 weeks and remained almost stable thereafter; a small number of osteoclasts were present in few specimens at each observation interval. Conclusions: the present findings demonstrated that great variability exits in man with respect to hard tissue formation within extraction sockets. Thus while a provisional connective tissue consistently forms within the first weeks of healing, the interval during which mineralized bone is laid down is much less predictable.
Modeling and Remodeling of Human Extraction Sockets.
TROMBELLI, Leonardo;FARINA, Roberto;MARZOLA, Andrea;
2008
Abstract
Introduction: the available studies on extraction wound repair in humans are affected by significant limitations and failed to evaluate tissue alterations occurring in all compartments of the hard tissue defect. Aim: monitor during a 6 month period the healing of human extraction sockets and include a semi-quantitative analysis of tissues and cell populations involved in various stages of the processes of modeling/remodeling. Materials & Methods: 27 biopsies, representative of the early (2-4 weeks; n= 10), intermediate (6-8 weeks; n= 6), and late phase (12-24 weeks; n= 11) of healing, were collected and analyzed. Results: granulation tissue that was present in comparatively large amounts in the early healing phase of socket healing, was in the interval between the early and intermediate observation phase replaced with provisional matrix and woven bone. The density of vascular structures and macrophages slowly decreased from 2-4 weeks over time. The presence of osteoblasts peaked at 6-8 weeks and remained almost stable thereafter; a small number of osteoclasts were present in few specimens at each observation interval. Conclusions: the present findings demonstrated that great variability exits in man with respect to hard tissue formation within extraction sockets. Thus while a provisional connective tissue consistently forms within the first weeks of healing, the interval during which mineralized bone is laid down is much less predictable.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
