To determinate the effect and the tolerability of intravenous omeprazole in the prevention of stress induced gastroduodenal lesions after elective major surgery, a randomized study with 28 patients has been carried out. The group A (14 cases) received 40 mg i.m. omeprazole daily from the day before surgery until oral administration was possible, there after omeprazole 20 mg tablets were delivered for other 7 days. The group B (14 cases) received 150 mg i.v. ranitidine daily and ranitidine 300 mg tablets according to the same protocol. No patients developed clinical findings of stress ulcer and no side effects were noted.
Omeprazolo iniettabile vs ranitidina nella profilassi perioperatoria dell'ulcera da stress
CARCOFORO, Paolo;ANANIA, Gabriele;
1993
Abstract
To determinate the effect and the tolerability of intravenous omeprazole in the prevention of stress induced gastroduodenal lesions after elective major surgery, a randomized study with 28 patients has been carried out. The group A (14 cases) received 40 mg i.m. omeprazole daily from the day before surgery until oral administration was possible, there after omeprazole 20 mg tablets were delivered for other 7 days. The group B (14 cases) received 150 mg i.v. ranitidine daily and ranitidine 300 mg tablets according to the same protocol. No patients developed clinical findings of stress ulcer and no side effects were noted.File in questo prodotto:
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