A review. In the last 5 years, many efforts were conducted searching potent and selective human A3 adenosine antagonists. In this field several different classes of compds., possessing very good affinity (nM range) and with a broad range of selectivity, were proposed. Recently, our group synthesized a new series of pyrazolo-triazolo-pyrimidines bearing different substitutions at the N5 and N8 positions, which were described as highly potent and selective human A3 adenosine receptor antagonists. The present review summarizes available data and provides an overview of the structure-activity relationships found for this class of human A3 adenosine receptor antagonists.
Pyrazolo-triazolo-pyrimidines as adenosine receptor antagonists: A complete structure-activity profile
CACCIARI, Barbara;
2007
Abstract
A review. In the last 5 years, many efforts were conducted searching potent and selective human A3 adenosine antagonists. In this field several different classes of compds., possessing very good affinity (nM range) and with a broad range of selectivity, were proposed. Recently, our group synthesized a new series of pyrazolo-triazolo-pyrimidines bearing different substitutions at the N5 and N8 positions, which were described as highly potent and selective human A3 adenosine receptor antagonists. The present review summarizes available data and provides an overview of the structure-activity relationships found for this class of human A3 adenosine receptor antagonists.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
