The presence of Chlamydia-like organism DNA was investigated by PCR in cerebrospinal fluid (CSF) samples from 25 patients who were already known to be positive for Chlamydia pneumoniae: 12 with multiple sclerosis (MS), grouped according to clinical and Magnetic Resonance Imaging (MRI) evidence of disease activity, 8 with other inflammatory neurological disorders (OIND) and 7 with non-inflammatory neurological disorders (NIND). A PCR evidence of Chlamydia-like organisms in CSF was found only in two relapsing-remitting MS patients with clinical and MRI disease activity. These findings suggest a possible association between C. pneumoniae and Chlamydia-like organisms brain infections as cofactor in MS development.
Molecular detection of Parachlamydia-like organisms in cerebrospinal fluid of patients with "multiple sclerosis"
CONTINI, Carlo;SERACENI, Silva;CULTRERA, Rosario;CASTELLAZZI, Massimiliano;GRANIERI, Enrico Gavino Giuseppe;FAINARDI, Enrico
2008
Abstract
The presence of Chlamydia-like organism DNA was investigated by PCR in cerebrospinal fluid (CSF) samples from 25 patients who were already known to be positive for Chlamydia pneumoniae: 12 with multiple sclerosis (MS), grouped according to clinical and Magnetic Resonance Imaging (MRI) evidence of disease activity, 8 with other inflammatory neurological disorders (OIND) and 7 with non-inflammatory neurological disorders (NIND). A PCR evidence of Chlamydia-like organisms in CSF was found only in two relapsing-remitting MS patients with clinical and MRI disease activity. These findings suggest a possible association between C. pneumoniae and Chlamydia-like organisms brain infections as cofactor in MS development.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
