The oxidation of racemic secondary alcohols with Bacillus stearothermophilus followed by reduction of the mixture with Yarrowia lipolytica to afford high yields of the enantiomerically pure R-alcohols is described. Comparisons with Yarrowia lipolytica reduction, Bacillus stearothermophilus oxidation, and the contemporary use of the two microrganisms have been made.
Combined Microbial Oxidation and Reduction: a New Approach to the High-yield Synthesis of Homochiral Unsaturated Secondary Alcohols from Racemates
FANTIN, Giancarlo;FOGAGNOLO, Marco;GIOVANNINI, Pier Paolo;MEDICI, Alessandro;PEDRINI, Paola
1995
Abstract
The oxidation of racemic secondary alcohols with Bacillus stearothermophilus followed by reduction of the mixture with Yarrowia lipolytica to afford high yields of the enantiomerically pure R-alcohols is described. Comparisons with Yarrowia lipolytica reduction, Bacillus stearothermophilus oxidation, and the contemporary use of the two microrganisms have been made.File in questo prodotto:
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