Human lymphocytes from either peripheral blood or continuous cultures (P3HR-1 cells) are able to support the replication of prototype polyomavirus BK (BKV) as well as its relates strain BO15 virus (BO15V). Instead, human monocytes from peripheral blood, although able to bind and engulf BKV virions, do not express virus-specific antigens within a 50 day observations period. In the light of these results, a probable role is suggested for human mononuclear blood cells in the mechanism of natural infection by polyomaviruses.
Restricted replication of BK virus in human lymphocytes
BORGATTI, Monica;GROSSI, Maria Pia;CORALLINI, Alfredo;BARBANTI BRODANO, Giuseppe
1985
Abstract
Human lymphocytes from either peripheral blood or continuous cultures (P3HR-1 cells) are able to support the replication of prototype polyomavirus BK (BKV) as well as its relates strain BO15 virus (BO15V). Instead, human monocytes from peripheral blood, although able to bind and engulf BKV virions, do not express virus-specific antigens within a 50 day observations period. In the light of these results, a probable role is suggested for human mononuclear blood cells in the mechanism of natural infection by polyomaviruses.File in questo prodotto:
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