Ependymomas were produced in 44 of 50 Syrian golden hamsters and in 9 of 31 outbred Swiss mice inoculated intracerebrally with high-titer, purified K virus (BKV). Tumors contained a T-antigen that reacted with BKV-specific T-antibody in immunofluorescence and complement-fixation tests. A proportion of tumor-bearing animals had antibodies to BKV-antigen in their sera. BKV could be rescued from two tumor cell lines by Sendai virus-mediated fusion with Vero cells. A low, or lack of, oncogenic activity was displayed by BKV incoulated sc, ip, or iv.
High incidence of ependymomas induced by BK virus, a human papovavirus: brief communication.
CORALLINI, Alfredo;BARBANTI BRODANO, Giuseppe;NENCI, Italo;CASSAI, Enzo;BORGATTI, Monica
1977
Abstract
Ependymomas were produced in 44 of 50 Syrian golden hamsters and in 9 of 31 outbred Swiss mice inoculated intracerebrally with high-titer, purified K virus (BKV). Tumors contained a T-antigen that reacted with BKV-specific T-antibody in immunofluorescence and complement-fixation tests. A proportion of tumor-bearing animals had antibodies to BKV-antigen in their sera. BKV could be rescued from two tumor cell lines by Sendai virus-mediated fusion with Vero cells. A low, or lack of, oncogenic activity was displayed by BKV incoulated sc, ip, or iv.File in questo prodotto:
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