In our opinion, none of the investigations existing in the current literature are able to conclusively verify the possibility of an interaction between NSAIDs and prostaglandin analogues. Particularly, the recent study of Chiba et al. is characterized by an insufficient and heterogeneous patient’s recruitment (just nine POAG and four ocular hypertension subjects), resembling the crucial weak-point of Kashiwagi and Tsukahara trial, which was previously conducted, by the same group, on healthy volunteers. Curiously, Chiba and co-workers have not considered these biases. On the contrary, they have emphasized, at the top of the Discussion section, that their “study clearly demonstrated that ophthalmic NSAID inhibits the IOP reduction by latanoprost ophthalmic solution in glaucomatous eyes”, partially or totally ignoring: i. the results of other Authors who had utilized a more numerous and/or homogeneous study populations; ii. the possible variability of PG receptors expression between different ethnic groups.
Effect of topical NSAID on IOP reduction by latanoprost.
COSTAGLIOLA, Ciro;PARMEGGIANI, Francesco
2006
Abstract
In our opinion, none of the investigations existing in the current literature are able to conclusively verify the possibility of an interaction between NSAIDs and prostaglandin analogues. Particularly, the recent study of Chiba et al. is characterized by an insufficient and heterogeneous patient’s recruitment (just nine POAG and four ocular hypertension subjects), resembling the crucial weak-point of Kashiwagi and Tsukahara trial, which was previously conducted, by the same group, on healthy volunteers. Curiously, Chiba and co-workers have not considered these biases. On the contrary, they have emphasized, at the top of the Discussion section, that their “study clearly demonstrated that ophthalmic NSAID inhibits the IOP reduction by latanoprost ophthalmic solution in glaucomatous eyes”, partially or totally ignoring: i. the results of other Authors who had utilized a more numerous and/or homogeneous study populations; ii. the possible variability of PG receptors expression between different ethnic groups.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
