Angioedema (AE) is caused by various stimulating agents that lead to the release of chemical mediators capable of increasing vascular permeability at cutaneous and/or mucosal level. The pathogenetic mechanisms involved, whether of an immunological or non-immunological nature, lead to a wide range of clinical features in which histamine and the histamine-releasing cells can be considered the principal protagonists. The pathogenesis of non-immunological AE includes a C1-inhibitor deficiency and pharmacological mechanisms. This definition suggests that the causal agent probably acts with a biochemical mechanism rather than a histaminergic one. The purpose of this review is to offer a general survey of drug-associated AE, induced by mechanisms of a pharmacological-biochemical nature without activation of the immune system or release of histamine.
Drug-induced non-histaminergic angioedema
ZAMPINO, Maria Rosaria;CORAZZA, Monica;VIRGILI, Anna
2004
Abstract
Angioedema (AE) is caused by various stimulating agents that lead to the release of chemical mediators capable of increasing vascular permeability at cutaneous and/or mucosal level. The pathogenetic mechanisms involved, whether of an immunological or non-immunological nature, lead to a wide range of clinical features in which histamine and the histamine-releasing cells can be considered the principal protagonists. The pathogenesis of non-immunological AE includes a C1-inhibitor deficiency and pharmacological mechanisms. This definition suggests that the causal agent probably acts with a biochemical mechanism rather than a histaminergic one. The purpose of this review is to offer a general survey of drug-associated AE, induced by mechanisms of a pharmacological-biochemical nature without activation of the immune system or release of histamine.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
