The microwave-promoted cyclization method has been used for the synthesis of a series of novel substituted 2,4-diarylthiazoles from -halo ketones and thioamides using ethanol as solvent. This rapid method produces compds. in good yield within one minute in comparison with conventional heating method. The synthesized mols. have been evaluated for their antiproliferative effects against five different cancer cell lines.
Microwave-assisted synthesis of substituted 2,4-diarylthiazoles and their evaluation as anticancer agents
ROMAGNOLI, Romeo;BARALDI, Pier Giovanni;PRETI, Delia;AGHAZADEH TABRIZI, Mojgan;
2007
Abstract
The microwave-promoted cyclization method has been used for the synthesis of a series of novel substituted 2,4-diarylthiazoles from -halo ketones and thioamides using ethanol as solvent. This rapid method produces compds. in good yield within one minute in comparison with conventional heating method. The synthesized mols. have been evaluated for their antiproliferative effects against five different cancer cell lines.File in questo prodotto:
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