The pathogenesis of vascular dementia (VD) is still uncompletely understood. In the present study, we investigated a number of risk factors, including four common DNA polymorphisms that have been associated with cardiovascular disease and dementia, in a sample of 88 older subjects affected by cerebrovascular disease, with (VD: n = 68) or without (WD: n = 20) vascular dementia. The diagnosis of VD was based on the NINDS-AIREN criteria. All subjects with VD had a Hachinski ischemic score over 7. The functional status was measured by the Barthel index. Subjects with VD were characterized by older ages (82.5 ± 0.8, SEM and 75.6 ± 1.4, SEM), lower Barthel score (8.1 ± 0.8 and 13.7 ± 1.5), and fewer years of education (4.6 ± 0.4 and 6.6 ± 0.7) as compared to WD, respectively. The prevalence of cerebral atrophy (72 vs 53%), lacunar infarctions (75 vs 53%), and leukoaraiosis (50 vs 26%) was higher in VD, as compared to WD. On the contrary, the prevalence of cortical-subcortical ischemic lesion...
Factors associated with dementia in subjects with cerebrovascular disease
ZULIANI, Giovanni;ZURLO A;FELLIN, Renato
2001
Abstract
The pathogenesis of vascular dementia (VD) is still uncompletely understood. In the present study, we investigated a number of risk factors, including four common DNA polymorphisms that have been associated with cardiovascular disease and dementia, in a sample of 88 older subjects affected by cerebrovascular disease, with (VD: n = 68) or without (WD: n = 20) vascular dementia. The diagnosis of VD was based on the NINDS-AIREN criteria. All subjects with VD had a Hachinski ischemic score over 7. The functional status was measured by the Barthel index. Subjects with VD were characterized by older ages (82.5 ± 0.8, SEM and 75.6 ± 1.4, SEM), lower Barthel score (8.1 ± 0.8 and 13.7 ± 1.5), and fewer years of education (4.6 ± 0.4 and 6.6 ± 0.7) as compared to WD, respectively. The prevalence of cerebral atrophy (72 vs 53%), lacunar infarctions (75 vs 53%), and leukoaraiosis (50 vs 26%) was higher in VD, as compared to WD. On the contrary, the prevalence of cortical-subcortical ischemic lesion...I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
