The reaction between 1-substituted and unsubstituted 3-(dimethylamino)/3,3-bis(methylthio)prop-2-en-1-ones and 4-substituted 5-amino-1H-pyrazoles afforded new pyrazole[1,5-a]pyrimidines structurally related to zaleplon. The chem. modifications introduced at the 3-, 5-, and 7-positions of the bicyclic structure revealed new promising candidates for the treatment of sleep disorders exhibiting 1-GABAA receptor affinity.
Synthesis of a new series of pyrazolo[1,5-a]pyrimidines structurally related to zaleplon
BARALDI, Pier Giovanni;FRUTTAROLO, Francesca;AGHAZADEH TABRIZI, Mojgan;ROMAGNOLI, Romeo;PRETI, Delia;BOREA, Pier Andrea
2007
Abstract
The reaction between 1-substituted and unsubstituted 3-(dimethylamino)/3,3-bis(methylthio)prop-2-en-1-ones and 4-substituted 5-amino-1H-pyrazoles afforded new pyrazole[1,5-a]pyrimidines structurally related to zaleplon. The chem. modifications introduced at the 3-, 5-, and 7-positions of the bicyclic structure revealed new promising candidates for the treatment of sleep disorders exhibiting 1-GABAA receptor affinity.File in questo prodotto:
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