myocarcÌilil inf:'uctiot). -'MI). Mosr previous $tu,clles have focusÌ:d en the early pcsteperatlve pltriod,wh.Ue ·d:tt2 en IniJ.-tçmi fOllQW-UP are 5C:U~ty.This study examined thcmid.-l:ermeffi:ctS of LAD ligatJon in· 95 Mr ·r;m and 25 cenerels, The followiog parameters were evaluared: syscernlc blood pressure (SE?Pì,.hean · rate (HR). and pla~ma: .brain narriurerlc peprlde (BNP) ,le.d.. Il: acldltilln, M-rt.Jodc and B·Ill(Jd~ eche<:ardicgr;lphy, hisrologic cxaminations, .llnCl è:udi:u; h.ydroxyproline assays wcre performd. Fòrty. .seven perloperarivc and 5 late deaehs were rccorded. Lefc'ventI:icular dHa-tion, observed l mo aftèr MI,did aot P!;"05r'CSS wirh tìme. Septal thickening wss su:nU(\r j n rhe Z groups, whìle wall rhickening was loVlec il! the MI rats at l rno onJy. StroI~ volume: was dìminished in MI racs, while cardlac ourpuc was dcprcssed only at I and 2 mo, due ec Inereased hean: rate. SBP was unchangoo and plasmil BNJllevcl was simìlar in che 2 groups. The jnfarcted area (mean ± SD) was 35 .± 10%. The vearriclcs .in MI rats were h~"Ier and ·had inereascd hydtoxypròl1ne ..r.o~~cnr. in conduslon, rhese data show that LAD Iigal~QJl is not only a .. .. modei of ~cute M[, but aI tl)id-tetm it prevides a model of dtro!1h::~chen7:ic dillitèd c3.l'qiomyopat:hy,
Experimental ischemic cardiomyopathy: Insights into remodeling, physiological adaptation, and humoral response
FERRARI, Roberto
2006
Abstract
myocarcÌilil inf:'uctiot). -'MI). Mosr previous $tu,clles have focusÌ:d en the early pcsteperatlve pltriod,wh.Ue ·d:tt2 en IniJ.-tçmi fOllQW-UP are 5C:U~ty.This study examined thcmid.-l:ermeffi:ctS of LAD ligatJon in· 95 Mr ·r;m and 25 cenerels, The followiog parameters were evaluared: syscernlc blood pressure (SE?Pì,.hean · rate (HR). and pla~ma: .brain narriurerlc peprlde (BNP) ,le.d.. Il: acldltilln, M-rt.Jodc and B·Ill(Jd~ eche<:ardicgr;lphy, hisrologic cxaminations, .llnCl è:udi:u; h.ydroxyproline assays wcre performd. Fòrty. .seven perloperarivc and 5 late deaehs were rccorded. Lefc'ventI:icular dHa-tion, observed l mo aftèr MI,did aot P!;"05r'CSS wirh tìme. Septal thickening wss su:nU(\r j n rhe Z groups, whìle wall rhickening was loVlec il! the MI rats at l rno onJy. StroI~ volume: was dìminished in MI racs, while cardlac ourpuc was dcprcssed only at I and 2 mo, due ec Inereased hean: rate. SBP was unchangoo and plasmil BNJllevcl was simìlar in che 2 groups. The jnfarcted area (mean ± SD) was 35 .± 10%. The vearriclcs .in MI rats were h~"Ier and ·had inereascd hydtoxypròl1ne ..r.o~~cnr. in conduslon, rhese data show that LAD Iigal~QJl is not only a .. .. modei of ~cute M[, but aI tl)id-tetm it prevides a model of dtro!1h::~chen7:ic dillitèd c3.l'qiomyopat:hy,I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
