An exhaustive insight into the pocket charge features of the methionine receptor using fMLP analogs.

Neutrophils play a key role as primary phagocytic cells, because they constitute the first line of defense against bacterial invasion, and contribute to inflammatory processes. the goal of the study herein reported is to clarify the features peculiar to the methionine receptor pocket. it has widley accepted that the L-Met residue seems to induce optimum chemotactic as well as secretory activities. the synthesised analogs, here reported, have clarified that the positively charged area in the Met pocket is i) narrow in dimension, ii) located at well defined distance from the backbone, and iii) oriented in a specific position, not completely surrounding the internally located said chain.