The enantioselective resolution of the racemic 1-heteroaryl- and 1-arylethanols 1a-h via microbial oxidation with Bacillus stearothermophilus to give the R-enantiomers with high enantiomeric excesses is described. The kinetic resolution of 1-(2-thienyl)ethanol 1b by oxidation with Acinetobacter calcoaceticus anitrat to S-enantiomer (ee 100%) is also reported. © 1993.
Microbial oxidation with Bacillus stearothermophilus: high enantioselective resolution of 1-heteroaryl and 1-aryl alcohols
FANTIN, Giancarlo;FOGAGNOLO, Marco;MEDICI, Alessandro;PEDRINI, Paola;
1993
Abstract
The enantioselective resolution of the racemic 1-heteroaryl- and 1-arylethanols 1a-h via microbial oxidation with Bacillus stearothermophilus to give the R-enantiomers with high enantiomeric excesses is described. The kinetic resolution of 1-(2-thienyl)ethanol 1b by oxidation with Acinetobacter calcoaceticus anitrat to S-enantiomer (ee 100%) is also reported. © 1993.File in questo prodotto:
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