It has been suggested that there is more than one type of dominant spinocerebellar ataxia, at least one of them controlled by a gene near the HLA region. In the family examined, linkage analysis was performed on the gene controlling the disease and some genetic markers, including the HLA system: a strong linkage (P=.002) between the disease gene and HLA was found. The data presented further support claims of the existence of at least one HLA-linked form of spinocerebellar ataxia.
HLA and spino-cerebellar ataxia: study of a family
Conighi C.;Granieri E.;Tola R.
1984
Abstract
It has been suggested that there is more than one type of dominant spinocerebellar ataxia, at least one of them controlled by a gene near the HLA region. In the family examined, linkage analysis was performed on the gene controlling the disease and some genetic markers, including the HLA system: a strong linkage (P=.002) between the disease gene and HLA was found. The data presented further support claims of the existence of at least one HLA-linked form of spinocerebellar ataxia.File in questo prodotto:
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