Loss of chromosome 6q was investigated in endometrial and ovarian carcinomas by a PCR based-microsatellite polymorphism analysis. Results obtained show that this technique is able to detect frequent loss of heterozygosity in the ovarian cancers (10/27) and only in the serous type (8/17). Then, this kind of analysis can contribute to the understanding of tumor development and progression of ovarian cancers with different histopathological features.
Loss of heterozygosity in ovarian cancer: detection by PCR and microsatellite polymorphism.
AGUIARI, Gianluca;BIANCHI, Nicoletta;CAVAZZINI, Luigi;MARTINELLO, Ruby;MOLLICA, Gioacchino;PIVA, Maria Roberta;DEL SENNO, Laura
1994
Abstract
Loss of chromosome 6q was investigated in endometrial and ovarian carcinomas by a PCR based-microsatellite polymorphism analysis. Results obtained show that this technique is able to detect frequent loss of heterozygosity in the ovarian cancers (10/27) and only in the serous type (8/17). Then, this kind of analysis can contribute to the understanding of tumor development and progression of ovarian cancers with different histopathological features.File in questo prodotto:
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