A highly efficient route is presented for the synthesis of N-protected isosteric dipeptides Pheψ[COCH2]Gly and Pheψ[CH(OH)CH2]Phe from L-phenylalanine through 2-thiazolyl α-amino ketone and δ-amino-γ-hydroxy-(E)-α,β-enoate derivatives as key intermediates. © 1992.
HOMOLOGATION OF L-PHENYLALANINE TO KETOMETHYLENE AND HYDROXYETHYLENE DIPEPTIDE ISOSTERES VIA 2-THIAZOLYL AMINO KETONE INTERMEDIATE
DONDONI, Alessandro;PERRONE, Daniela
1992
Abstract
A highly efficient route is presented for the synthesis of N-protected isosteric dipeptides Pheψ[COCH2]Gly and Pheψ[CH(OH)CH2]Phe from L-phenylalanine through 2-thiazolyl α-amino ketone and δ-amino-γ-hydroxy-(E)-α,β-enoate derivatives as key intermediates. © 1992.File in questo prodotto:
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