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The Free-Wilson model has been applied to the analysis of activity data of 55 benzodiazepines derived from Footshock, Inclined Screen and Pentylenetetrazole tests. The comparison of the individual group contributions shows a similar trend for Footshock and Inclined Screen tests, while some differences are observed with respect to the Pentylenetetrazole test. The most relevant differences seem to be associated with the presence of highly electron-withdrawing substituents in positions 7 and 2'.
Application of the Free Wilson Model to the analysis of three different pharmacological activities tests in benzodiazepines
Borea P. A.;Gilli G.;Bertolasi V.
1979
Abstract
The Free-Wilson model has been applied to the analysis of activity data of 55 benzodiazepines derived from Footshock, Inclined Screen and Pentylenetetrazole tests. The comparison of the individual group contributions shows a similar trend for Footshock and Inclined Screen tests, while some differences are observed with respect to the Pentylenetetrazole test. The most relevant differences seem to be associated with the presence of highly electron-withdrawing substituents in positions 7 and 2'.File in questo prodotto:
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