The β-adrenergic blocking potency of 56 1-substituted ureidophenoxy-3-amino-2-propanols has been analysed in terms of the linear Free-Wilson model. The values obtained for the Free-Wilson coefficients have been correlated with the chemico-physical parameters of the substituents. The preliminary indication given by the Free-Wilson analysis has been confirmed by a quantitative regression analysis, carried out in the frame of the 'mixed approach' method.
Quantitative structure activity relationships in 1-substituted ureidophenoxy-3-amino-2-propanols, a class of beta adrenergic blocking agents
BOREA, Pier Andrea;BONORA, Angelo;BERTOLASI, Valerio;GILLI, Gastone
1980
Abstract
The β-adrenergic blocking potency of 56 1-substituted ureidophenoxy-3-amino-2-propanols has been analysed in terms of the linear Free-Wilson model. The values obtained for the Free-Wilson coefficients have been correlated with the chemico-physical parameters of the substituents. The preliminary indication given by the Free-Wilson analysis has been confirmed by a quantitative regression analysis, carried out in the frame of the 'mixed approach' method.File in questo prodotto:
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