The chromatographic RM values of a series of nitroimidazoles and their log P values were determined in view of a study of their structure-activity relationships as mutagenic agents. The equations describing the relationship between RM and log P values show a low correlation coefficient. The introduction of the molar refractivity of the R1 and R2 groups yields a significant improvement in the correlation coefficient. The molar refractivity could be an expression of the adsorption activity of the silica gel layer. © 1981.
Rm and logP values of 5-nitroimidazoles
BOREA, Pier Andrea;
1981
Abstract
The chromatographic RM values of a series of nitroimidazoles and their log P values were determined in view of a study of their structure-activity relationships as mutagenic agents. The equations describing the relationship between RM and log P values show a low correlation coefficient. The introduction of the molar refractivity of the R1 and R2 groups yields a significant improvement in the correlation coefficient. The molar refractivity could be an expression of the adsorption activity of the silica gel layer. © 1981.File in questo prodotto:
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