The activity pattern of 8 dermorphin related tetrapeptides was determined in guinea-pig ileum and mouse vas deferens bioassays. Naloxone was a powerful antagonist of all compounds in both preparations. Moreover, the biological activities of the test compounds were correlated in a statistically significant way to the lipophilic character of the C-terminal substituents.
Pharmacological studies of a series of dermorphin related tetrapeptides
SARTO, Gianpietro;BOREA, Pier Andrea;SALVADORI, Severo;TOMATIS, Roberto
1983
Abstract
The activity pattern of 8 dermorphin related tetrapeptides was determined in guinea-pig ileum and mouse vas deferens bioassays. Naloxone was a powerful antagonist of all compounds in both preparations. Moreover, the biological activities of the test compounds were correlated in a statistically significant way to the lipophilic character of the C-terminal substituents.File in questo prodotto:
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