Flunitrazepam, a benzodiazepine agonist increases, and DMCM, an inverse agonist decreases the stimulation by etazolate or pentobarbital of [3H]muscimol binding to membranes of rat cerebral cortex. Ro 15-1788 has no marked effects but antagonizes the action of both flunitrazepam and DMCM. The investigation of several drugs acting on benzodiazepine receptors on etazolate enhancement of [3H]muscimol binding suggests that their receptor interaction reflects a spectrum from agonists to inverse agonists. © 1983.
Differential modulation of etazolate or pentobarbital enhanced 3H-muscimol binding by benzodiazepine agonists and inverse agonists
BOREA, Pier Andrea;
1983
Abstract
Flunitrazepam, a benzodiazepine agonist increases, and DMCM, an inverse agonist decreases the stimulation by etazolate or pentobarbital of [3H]muscimol binding to membranes of rat cerebral cortex. Ro 15-1788 has no marked effects but antagonizes the action of both flunitrazepam and DMCM. The investigation of several drugs acting on benzodiazepine receptors on etazolate enhancement of [3H]muscimol binding suggests that their receptor interaction reflects a spectrum from agonists to inverse agonists. © 1983.File in questo prodotto:
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