Chromatographic RM values were measured for a series of 41 cardiac glycosides and aglycones. By means of the ΔRM values it was possible to calculate the RM values for a further 19 compounds. An excellent correlation was found between the present RM values and those measured or calculated with the Cohnen et al. system. In a similar way, the RM values were shown to be well correlated with both high-performance liquid chromatographic data octanol-water partition coefficients (log P). The additive contribution of each substituent group to the overall lipophilicity of the molecule seems to be constant in each subset of Digitalis derivatives. © 1990.
Lipophilic character of cardiac glycosides. RM values as lipophilicity parameters
BOREA, Pier Andrea;
1990
Abstract
Chromatographic RM values were measured for a series of 41 cardiac glycosides and aglycones. By means of the ΔRM values it was possible to calculate the RM values for a further 19 compounds. An excellent correlation was found between the present RM values and those measured or calculated with the Cohnen et al. system. In a similar way, the RM values were shown to be well correlated with both high-performance liquid chromatographic data octanol-water partition coefficients (log P). The additive contribution of each substituent group to the overall lipophilicity of the molecule seems to be constant in each subset of Digitalis derivatives. © 1990.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
