A new series of 1,4-dihydropyridine bearing substituted pyrazole and imidazole at C-4 position was synthesized and characterized as inotropic, chronotropic and calcium antagonist agents, in order to evaluate the effect on pharmacol. activity of replacement of the 4-aryl group of nifedipine-like drugs by pyrazole and imidazole moieties. All compds. were tested on myocardial muscle and vascular smooth muscle of guinea-pigs. The new compds. showed both significant selective neg. inotropic activity and fairly good neg. chronotropic effects. All compds. elicited weak calcium antagonist activity, except one compd. which is a selective bradycardic agent.
Synthesis and cardiodepressant activity of dialkyl 1,4-dihydro-2,6-dimethyl-4-(pentatomic-heteroaryl)-3,5-pyridinedicarboxylates. 2
BARALDI, Pier Giovanni;CACCIARI, Barbara;
1993
Abstract
A new series of 1,4-dihydropyridine bearing substituted pyrazole and imidazole at C-4 position was synthesized and characterized as inotropic, chronotropic and calcium antagonist agents, in order to evaluate the effect on pharmacol. activity of replacement of the 4-aryl group of nifedipine-like drugs by pyrazole and imidazole moieties. All compds. were tested on myocardial muscle and vascular smooth muscle of guinea-pigs. The new compds. showed both significant selective neg. inotropic activity and fairly good neg. chronotropic effects. All compds. elicited weak calcium antagonist activity, except one compd. which is a selective bradycardic agent.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
