A new series of 4-(nitrogenous heteroaryl)-1,4-dihydropyridine (I, R1 = e.g., indol-2-yl, quinolin-4-yl, quinoxalin-5-yl, R1 = Me or Et) antagonists were synthesized and screened for inotropic, chronotropic and calcium antagonist properties, in order to evaluate the effect on pharmacol. activity of replacement of the 4-aryl group of nifedipine-like drugs by heterocyclic moieties, such as quinoline, indole, carbazole and pyrazole. The most potent bradycardic compds. of the series elicited weak calcium antagonist activity and were stronger neg. inotropic.
Synthesis and calcium antagonist activity of dialkyl 1,4-dihydro-2,6-dimethyl-4-(nitrogenous heteroaryl)-3,5-pyridine dicarboxylates.
BARALDI, Pier Giovanni;CACCIARI, Barbara;
1992
Abstract
A new series of 4-(nitrogenous heteroaryl)-1,4-dihydropyridine (I, R1 = e.g., indol-2-yl, quinolin-4-yl, quinoxalin-5-yl, R1 = Me or Et) antagonists were synthesized and screened for inotropic, chronotropic and calcium antagonist properties, in order to evaluate the effect on pharmacol. activity of replacement of the 4-aryl group of nifedipine-like drugs by heterocyclic moieties, such as quinoline, indole, carbazole and pyrazole. The most potent bradycardic compds. of the series elicited weak calcium antagonist activity and were stronger neg. inotropic.File in questo prodotto:
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