A newly developed selective NK2 receptor agonist was investigatd with regard to various physiological parameters in anaesthetised rats and guinea-pigs. The compund was as active, or more than NKA or NKA(4-10) in producing rat bladder contraction or bronchospasm in guinea-pigs (NK2 effects). Otherwise, it was almost inactive in producing hypotension of plasma extravasation in rat bladder, as well as salivation in guinea-pigs (NK1 effects). Therefore this new agonist can be used to explore the distribution and function of NK-2 receptors.
In vivo pharmacology of [bAla8]neurokinin A-(4-10), a selective NK-2 tachykinin receptor agonist.
ABELLI, Luigi;
1990
Abstract
A newly developed selective NK2 receptor agonist was investigatd with regard to various physiological parameters in anaesthetised rats and guinea-pigs. The compund was as active, or more than NKA or NKA(4-10) in producing rat bladder contraction or bronchospasm in guinea-pigs (NK2 effects). Otherwise, it was almost inactive in producing hypotension of plasma extravasation in rat bladder, as well as salivation in guinea-pigs (NK1 effects). Therefore this new agonist can be used to explore the distribution and function of NK-2 receptors.File in questo prodotto:
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