This study explored the relationship between blood eosinophil counts, airway eosinophilic activation, and exacerbation phenotypes in COPD. Higher stable-state blood eosinophils were associated with increased sputum EPX, supporting EPX as a marker of eosinophilic airway inflammation. In addition, sputum IL-5 was higher in patients with eosinophilic exacerbations, including those with low stable-state blood eosinophils, indicating discordance between blood and airway markers. These findings suggest that eosinophilic exacerbators represent a distinct Th2-driven phenotype that may benefit from targeted biologic therapies.
S64 Eosinophil peroxidase and IL-5 as biomarkers of eosinophilic airway inflammation in COPD
Baraldi, F
Primo
;Papi, A;
2024
Abstract
This study explored the relationship between blood eosinophil counts, airway eosinophilic activation, and exacerbation phenotypes in COPD. Higher stable-state blood eosinophils were associated with increased sputum EPX, supporting EPX as a marker of eosinophilic airway inflammation. In addition, sputum IL-5 was higher in patients with eosinophilic exacerbations, including those with low stable-state blood eosinophils, indicating discordance between blood and airway markers. These findings suggest that eosinophilic exacerbators represent a distinct Th2-driven phenotype that may benefit from targeted biologic therapies.File in questo prodotto:
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