25-Hydroxyvitamin D serum levels inversely correlate to disease severity and serum C-reactive protein levels in patients with hidradenitis suppurativa

Vitamin D exerts functions in skin physiology by modulating keratinocyte proliferation and different immunoregulatory processes. In several dermatoses, vitamin D correlates to disease severity and is significantly lower if compared to healthy subjects.2Hidradenitis suppurativa (HS) is a chronic inflammatory disease characterized by painful suppurating lesions mainly localized in the folds. Kelly et al. conducted the first study assessing vitamin D status in HS, concluding that 75% of patients had vitamin D levels of less than 50 nmol/L compared to 40% of the general population.