The combined effects of hyperbaric treatment and timolol maleate administration on the severity of retinopathy induced by exposure to 80% oxygen were studied in newborn Wistar rats. A group of newborn rats was exposed to hyperoxia (FIO2 80% under hyperbaric conditions (+40.5 KkPa) for the first five days of life and then to room air conditions for the subsequent five days. During this ten-day period one drop of timolol maleate 0.25% was instilled in each eye twice daily. Seventy-two percent of the newborn rats treated in this way failed to develop oxygen-induced retinopathy (OIR). In the other 28% OIR was present but it was less severe than that observed in the other identically oxygenated group that did not receive timolol maleate in hyperbaric conditions. We believe that the improvement in ocular perfusion pressure that did not receive timolol maleate in hyperbaric conditions. We believe that the improvement in ocular perfusion pressure may modulate retinal blood low and attenuate the effects of oxygen on the immature retinal vessels.
Role of ocular perfusion pressure on the severity of oxygen-induced retinopathy in the newborn rat
Quaranta Leoni F.;
1992
Abstract
The combined effects of hyperbaric treatment and timolol maleate administration on the severity of retinopathy induced by exposure to 80% oxygen were studied in newborn Wistar rats. A group of newborn rats was exposed to hyperoxia (FIO2 80% under hyperbaric conditions (+40.5 KkPa) for the first five days of life and then to room air conditions for the subsequent five days. During this ten-day period one drop of timolol maleate 0.25% was instilled in each eye twice daily. Seventy-two percent of the newborn rats treated in this way failed to develop oxygen-induced retinopathy (OIR). In the other 28% OIR was present but it was less severe than that observed in the other identically oxygenated group that did not receive timolol maleate in hyperbaric conditions. We believe that the improvement in ocular perfusion pressure that did not receive timolol maleate in hyperbaric conditions. We believe that the improvement in ocular perfusion pressure may modulate retinal blood low and attenuate the effects of oxygen on the immature retinal vessels.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
