Heterogeneous patterning of blood-brain barrier and adaptive myelination as renewing key in gray and white matter

Development and homeostasis of the brain are enabled through the precise control of the cell microenvironment by the blood-brain barrier (BBB), which interfaces between the brain parenchyma and the lumen of blood microvessels, and by the blood-cerebrospinal fluid barrier, which separates the cerebrospinal fluid from the blood vessels of the choroid plexus. Here, the focus will be on the BBB, the impairment of which is considered the earliest common denominator in neurovascular diseases.